HLA class I genotypes in Leber's hereditary optic neuropathy

被引：5

作者：

Chalmers, RM ^{[1
]}

Govan, GG ^{[1
]}

Schapira, AHV ^{[1
]}

Harding, AE ^{[1
]}

机构：

[1] ROYAL FREE HOSP,SCH MED,DEPT CLIN NEUROSCI,LONDON,ENGLAND

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1996年 / 135卷 / 02期

基金：

英国惠康基金;

关键词：

Leber's hereditary optic neuropathy; HLA class I;

D O I：

10.1016/0022-510X(95)00286-B

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There is evidence that mitochondrial DNA (mtDNA) encoded peptides can restrict the immune response in rodents and that these peptides are presented by classical and 'neoclassical: class I major histocompatibility complex (MHC) molecules. We investigated the frequency of HLA-A and two HLA-B genotypes in index cases of 77 families with Leber's hereditary optic neuropathy (LHON), on the basis that there may be an autoimmune component to this disease. There was no association between LHON and any genotype. We conclude that the classical class I MHC loci are not major determinants of the development of blindness in LHON.

引用

页码：173 / 175

页数：3

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