Nitric oxide signaling and the regulation of myocardial function

被引：103
|
作者：
Ziolo, Mark T. [1 ]
Kohr, Mark J. [1 ]
Wang, Honglan [1 ]
机构：
[1] Ohio State Univ, Davis Heart & Lung Res Inst, Dept Physiol & Cell Biol, Columbus, OH 43210 USA
来源：
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2008年 / 45卷 / 05期
基金：
美国国家卫生研究院;
关键词：
NOS; Peroxynitrite; cGMP; Excitation-contraction coupling; L-type Ca2+ channel; Phospholamban; Ryanodine receptor;
D O I：
10.1016/j.yjmcc.2008.07.015
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Nitric oxide, which is produced endogenously within cardiac myocytes by three distinct isoforms of nitric oxide synthase, is a key regulator of myocardial function. This review will focus on the regulation of myocardial function by each nitric oxide synthase isoform during health and disease, with a specific emphasis on the proposed end-targets and signaling pathways. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：625 / 632
页数：8
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