Positive elements in the laminin gamma 1 gene synergize to activate high level transcription during cellular differentiation

被引：13

作者：

Chang, HS ^{[1
]}

Kim, NB ^{[1
]}

Phillips, SL ^{[1
]}

机构：

[1] UNIV PITTSBURGH, SCH MED, DEPT MOLEC GENET & BIOCHEM, PITTSBURGH, PA 15261 USA

来源：

NUCLEIC ACIDS RESEARCH | 1996年 / 24卷 / 07期

关键词：

D O I：

10.1093/nar/24.7.1360

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transcription of the murine laminin gamma 1 gene is activated during retinoic acid/cAMP induced differentiation of F9 embryonal carcinoma cells, Positive transcription control elements associated with two DNase I hypersensitive regions in the large first intron of the gene have been identified which confer a differentiation response on the laminin gamma 1 promoter, However, the kinetics of transcriptional activation suggest each DNA region interacts with transcription factors appearing at different times during differentiation, Synergy between the two regions in cis causes high level activation.

引用

页码：1360 / 1368

页数：9

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