Elevation of serum oxidative stress in patients with retina vein occlusions

被引：19

作者：

Chen, Kuan-Hsuan ^{[1
,2
,3
]}

Hsiang, En-Lin ^{[2
,4
]}

Hsu, Min-Yen ^{[5
,6
]}

Chou, Yueh-Ching ^{[2
,3
,7
]}

Lin, Tai-Chi ^{[1
,8
]}

Chang, Yuh-Lih ^{[2
,3
]}

Tsai, Ching-Yao ^{[4
,9
]}

Li, Tzu-Hsuan ^{[4
,5
]}

Woung, Lin-Chung ^{[4
,9
]}

Chen, Shih-Jen ^{[4
,8
]}

Peng, Chi-Hsien ^{[10
,11
]}

Hwang, De-Kuang ^{[4
,8
]}

机构：

[1] Natl Yang Ming Univ, Inst Clin Med, Taipei, Taiwan

[2] Natl Yang Ming Univ, Inst Pharmacol, Taipei, Taiwan

[3] Taipei Vet Gen Hosp, Dept Pharm, Taipei, Taiwan

[4] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan

[5] Chung Shan Med Univ Hosp, Dept Ophthalmol, Taichung, Taiwan

[6] Chung Shan Med Univ, Sch Med, Taichung, Taiwan

[7] Taipei Med Univ, Sch Pharm, Taipei, Taiwan

[8] Taipei Vet Gen Hosp, Dept Ophthalmol, 201,Sec 2,Shih Pai Rd, Taipei 11217, Taiwan

[9] Taipei City Hosp, Dept Ophthalmol, Taipei, Taiwan

[10] Shin Kong Wu Ho Su Mem Hosp, Dept Ophthalmol, Taipei, Taiwan

[11] Fu Jen Catholic Univ, Taipei, Taiwan

来源：

ACTA OPHTHALMOLOGICA | 2019年 / 97卷 / 02期

关键词：

oxidative stress; retinal vein occlusions; RISK-FACTOR; SIRT1; INJURY; DAMAGE; DNA;

D O I：

10.1111/aos.13892

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose Retina vein occlusion (RVO) is a visual-threatening retinal disease that causes irreversible impaired quality of life. The contribution of oxidative stress behind clinical course of RVO was rarely investigated. The study aimed to measure the serum oxidative biomarker in patients with RVO to investigate further physical response. Methods We measured the serum levels of malondialdehyde (MDA), 8-hydroxy-2-deoxyguanosine (8OHdG), Sirutin 1 (SIRT1), peroxisome proliferator- activated receptor gamma (PPAR-r), Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha), orkhead box protein O1 (FOXO1), orkhead box protein O3 (FOXO3), catalase, (SOD) and hydrogen peroxide (H2O2) among 19 patients with cataract as control group and 36 patients with RVO, respectively. Results The mean MDA, 8OHdG and hydrogen peroxide in the serum were significantly higher in patients with RVO compared with the results in control group subjects. Whereas SIRT1, PPAR-r, PGC-1, FOXO1, FOXO3, catalase and SOD levels in serum were significantly decreased in patients with RVO compared with control group. Conclusion We demonstrated that the serum level of MDA, 8OHdG and hydrogen peroxide is increased in patients with RVO. Among these, the elevation of MDA, 8OHdG and hydrogen peroxide suggests the increasing of serum oxidative stress in RVO patients. All enzymes related reactive oxygen species scavenge were decreased. Thus, focal RVO may increase systemic oxidative stress within serum.

引用

页码：E290 / E295

页数：6

共 19 条

[1] Chemerin induces CCL2 and TLR4 in synovial fibroblasts of patients with rheumatoid arthritis and osteoarthritis [J].