Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure-Activity Relationships and Discovery Strategies To Mitigate Drug-Drug Interaction Risks

被引：166

作者：

Orr, Suvi T. M. ^{[2
]}

Ripp, Sharon L. ^{[3
]}

Ballard, T. Eric ^{[2
]}

Henderson, Jaclyn L. ^{[2
]}

Scott, Dennis O. ^{[1
]}

Obach, R. Scott ^{[3
]}

Sun, Hao ^{[3
]}

Kalgutkar, Amit S. ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Pharmacokinet Dynam & Metab, Cambridge, MA 02139 USA

[2] Pfizer Global Res & Dev, Worldwide Med Chem, Groton, CT 06340 USA

[3] Pfizer Global Res & Dev, Pharmacokinet Dynam & Metab, Groton, CT 06340 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 55卷 / 11期

关键词：

TIME-DEPENDENT INHIBITION; HUMAN-LIVER-MICROSOMES; IN-VITRO DATA; IMMUNODEFICIENCY-VIRUS-PROTEASE; COVALENT MODIFICATION; METABOLIZING-ENZYMES; SUICIDE INACTIVATION; CLINICAL PHARMACOKINETICS; PLASMA-CONCENTRATIONS; RENIN INHIBITORS;

D O I：

10.1021/jm300065h

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：4896 / 4933

页数：38

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