SJS']JS/TEN 2019: From science to translation

被引：49

作者：

Chang, Wan-Chun ^{[1
,2
]}

Abe, Riichiro ^{[3
]}

Anderson, Paul ^{[4
]}

Anderson, Wanpen ^{[4
]}

Ardern-Jones, Michael R. ^{[5
]}

Beachkofsky, Thomas M. ^{[6
]}

Bellon, Teresa ^{[7
]}

Biala, Agnieszka K. ^{[1
,2
]}

Bouchard, Charles ^{[8
]}

Cavalleri, Gianpiero L. ^{[9
,10
]}

Chapman, Nicole ^{[11
]}

Chodosh, James ^{[12
]}

Choi, Hyon K. ^{[13
]}

Cibotti, Ricardo R. ^{[14
]}

Divito, Sherrie J. ^{[15
]}

Dewar, Karen ^{[16
]}

Dehaeck, Ulrike ^{[17
]}

Etminan, Mahyar ^{[18
]}

Forbes, Diane ^{[19
]}

Fuchs, Esther ^{[20
]}

Goldman, Jennifer L. ^{[21
]}

Holmes, James H. ^{[22
]}

Hope, Elyse A. ^{[23
]}

Hung, Shuen-Iu ^{[24
,25
]}

Hsieh, Chia-Ling ^{[26
]}

Iovieno, Alfonso ^{[27
]}

Jagdeo, Julienne ^{[23
]}

Kim, Mee Kum ^{[28
]}

Koelle, David M. ^{[29
]}

Lacouture, Mario E. ^{[30
]}

Le Pallec, Sophie ^{[31
]}

Lehloenya, Rannakoe J. ^{[32
]}

Lim, Robyn ^{[33
]}

Lowe, Angie ^{[34
]}

McCawley, Jean ^{[4
]}

McCawley, Julie ^{[4
]}

Micheletti, Robert G. ^{[35
]}

Mockenhaupt, Maja ^{[36
,37
]}

Niemeyer, Katie ^{[38
]}

Norcross, Michael A. ^{[39
]}

Oboh, Douglas ^{[4
]}

Olteanu, Cristina ^{[40
]}

Pasieka, Helena B. ^{[41
]}

Peter, Jonathan ^{[42
]}

Pirmohamed, Munir ^{[43
]}

Rieder, Michael ^{[44
]}

Saeed, Hajirah N. ^{[12
]}

Shear, Neil H. ^{[45
]}

Shieh, Christine ^{[46
]}

Straus, Sabine ^{[47
]}

机构：

[1] Univ British Columbia, Fac Med, Dept Pediat, Div Translat Therapeut, Vancouver, BC, Canada

[2] British Columbia Childrens Hosp, Res Inst, Vancouver, BC, Canada

[3] Niigata Univ, Grad Sch Med & Dent Sci, Niigata, Japan

[4] Stevens Johnson Syndrome Fdn, Westminster, CO USA

[5] Univ Southampton, Southampton Gen Hosp, Fac Med, Southampton, Hants, England

[6] Wilford Hall Ambulatory Surg Ctr, Lackland AFB, TX USA

[7] Hosp La Paz Inst Hlth Res IdiPAZ, Drug Hypersensit Grp, Madrid, Spain

[8] Loyola Univ, Med Ctr, Chicago, IL 60611 USA

[9] Royal Coll Surgeons Ireland, Sch Pharm & Mol & Cellular Therapeut, Dublin, Ireland

[10] Royal Coll Surgeons Ireland, FutureNeuro SFI Res Ctr, Dublin, Ireland

[11] SJS Awareness Oregon, Klamath Falls, OR USA

[12] Harvard Med Sch, Massachusetts Eye & Ear, Boston, MA 02115 USA

[13] Massachusetts Gen Hosp, Div Rheumatol Allergy & Immunol, Boston, MA 02114 USA

[14] NIAMSD, NIH, Bethesda, MD 20892 USA

[15] Harvard Med Sch, Brigham & Womens Hosp, Dept Dermatol, Boston, MA 02115 USA

[16] Genome Canada, Ottawa, ON, Canada

[17] Univ British Columbia, Dept Obstet & Gynecol, Vancouver, BC, Canada

[18] Univ British Columbia, Dept Ophthalmol & Visual Sci, Vancouver, BC, Canada

[19] Canadian Inst Hlth Res, Ottawa, ON, Canada

[20] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA

[21] Childrens Mercy Hosp, Kansas City, MO 64108 USA

[22] Wake Forest Univ, Bowman Gray Sch Med, WFBMC Burn Ctr, Winston Salem, NC USA

[23] Genome British Columbia, Vancouver, BC, Canada

[24] Chang Gung Mem Hosp, Canc Vaccine & Immune Cell Therapy Core Lab, Chang Gung Immunol Consortium, Taoyuan, Taiwan

[25] Natl Yang Ming Univ, Inst Pharmacol, Taipei, Taiwan

[26] Eden Social Welf Fdn, Taipei, Taiwan

[27] Univ British Columbia, Vancouver Gen Hosp Eye Care Ctr, Dept Ophthalmol & Visual Sci, Vancouver, BC, Canada

[28] Seoul Natl Univ, Dept Ophthalmol, Coll Med, Seoul, South Korea

[29] Univ Washington, Dept Med, Seattle, WA USA

[30] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA

[31] Assoc Malad Syndromes Lyell & Stevens Johnson Ama, Paris, France

[32] Univ Cape Town, Dept Med, Div Dermatol, Cape Town, South Africa

[33] Hlth Canada, Hlth Prod & Food Branch, Ottawa, ON, Canada

[34] SJS TEN Int Awareness STIA, Lucky Lake, SK, Canada

[35] Univ Penn, Dept Dermatol, Perelman Sch Med, Philadelphia, PA 19104 USA

[36] Univ Freiburg, Med Ctr, Dept Dermatol, Dokumentat Zentrum Schwerer Hautreakt dZh, Freiburg, Germany

[37] Univ Freiburg, Med Fac, Freiburg, Germany

[38] SJ Syndrome Texas, Austin, TX USA

[39] US FDA, Lab Immunol, Div Biotechnol Review & Res 3, OBP,OPQ,Ctr Drug Evaluat & Res, Silver Spring, MD USA

[40] Univ Alberta, Dept Med, Div Dermatol, Edmonton, AB, Canada

[41] MedStar Washington Hosp Ctr, Dept Dermatol, Washington, DC USA

[42] Univ Cape Town, Dept Med, Div Allergy & Clin Immunol, Cape Town, South Africa

[43] Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool, Merseyside, England

[44] Western Univ, Childrens Hosp, Schulich Sch Med & Dent, Dept Paediat,London Hlth Sci Ctr, London, ON, Canada

[45] Univ Toronto, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada

[46] Vanderbilt Eye Inst, Dept Ophthalmol, Nashville, TN USA

[47] European Med Agcy, Pharmacovigilance Risk Assessment Comm, Dutch Med Evaluat Board, Utrecht, Netherlands

[48] Mahidol Univ, Ramathibodi Hosp, Bangkok, Thailand

[49] Duke NUS Med Sch, Hlth Sci Author Singapore, Hlth Prod Regulat Grp, Singapore, Singapore

[50] Austin Hlth, Dept Infect Dis, Heidelberg, Germany

来源：

JOURNAL OF DERMATOLOGICAL SCIENCE | 2020年 / 98卷 / 01期

基金：

英国医学研究理事会;

关键词：

Stevens-Johnson syndrome (S[!text type='JS']JS[!/text]); Toxic epidermal necrolysis (TEN); Human leukocyte antigen (HLA); Pharmacogenomics; Pharmacovigilance; Severe cutaneous adverse reaction (SCAR); STEVENS-JOHNSON-SYNDROME; TOXIC EPIDERMAL NECROLYSIS; RISK; HYPERSENSITIVITY; COMPLICATIONS; INVOLVEMENT; GRANULYSIN; SURVIVORS; SCARS; CARE;

D O I：

10.1016/j.jdermsci.2020.02.003

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are potentially life-threatening, immune-mediated adverse reactions characterized by widespread erythema, epidermal necrosis, and detachment of skin and mucosa. Efforts to grow and develop functional international collaborations and a multidisciplinary interactive network focusing on SJS/TEN as an uncommon but high burden disease will be necessary to improve efforts in prevention, early diagnosis and improved acute and long-term management. SJS/TEN 2019: From Science to Translation was a 1.5-day scientific program held April 26-27, 2019, in Vancouver, Canada. The meeting successfully engaged clinicians, researchers, and patients and conducted many productive discussions on research and patient care needs. Crown Copyright (C) 2020 Published by Elsevier B.V. on behalf of Japanese Society for Investigative Dermatology. All rights reserved.

引用

页码：2 / 12

页数：11

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