Oral polio vaccine response in breast fed infants with malnutrition and diarrhea

被引：48

作者：

Haque, Rashidul ^{[1
]}

Snider, Cynthia ^{[2
]}

Liu, Yue ^{[2
]}

Ma, Jennie Z. ^{[2
]}

Liu, Lei ^{[3
]}

Nayak, Uma ^{[2
]}

Mychaleckyj, Josyf C. ^{[2
]}

Korpe, Poonum ^{[2
]}

Mondal, Dinesh ^{[1
]}

Kabir, Mamun ^{[1
]}

Alam, Masud ^{[1
]}

Pallansch, Mark ^{[4
]}

Oberste, M. Steven ^{[4
]}

Weldon, William ^{[4
]}

Kirkpatrick, Beth D. ^{[5
]}

Petri, William A., Jr. ^{[2
]}

机构：

[1] Int Ctr Diarrhoeal Dis Res, Dhaka 1000, Bangladesh

[2] Univ Virginia, Charlottesville, VA USA

[3] Northwestern Univ, Chicago, IL 60611 USA

[4] Ctr Dis Control & Prevent, Atlanta, GA USA

[5] Univ Vermont, Coll Med, Burlington, VT USA

来源：

VACCINE | 2014年 / 32卷 / 04期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

BANGLADESHI INFANTS; HUMAN ROTAVIRUS; ENTEROPATHY; INFECTION; CHILDREN; MILK;

D O I：

10.1016/j.vaccine.2013.11.056

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Oral vaccines for polio (OPV) and rotavirus are less effective in children in the developing world. The reasons for this are not well understood. We tested for risk factors for poor response to OPV in infants from an urban slum of Dhaka, Bangladesh. Diminished serum neutralizing response to OPV, but not failure of intramuscularly administered vaccines, was associated with malnutrition, diarrhea, and shorter breastfeeding duration. Children with malnutrition (WAZ < -2) had significantly lower OPV 3 titers (p = 0.029). Children who had 2 or more diarrhea episodes during the 1st months of life were more than twice as likely to experience OPV failure as those who had 1 diarrhea episode or no diarrhea (p = 0.0245). In contrast, each additional month in exclusive breastfeeding was associated with an increase in OPV 3 titer by 0.41 (p = 0.0072) and 0.16 (p = 0.0065) at the 25th and 50th percentiles of OPV 3 titers respectively. These data are consistent with a defect in induction of immunity in the gut for OPV but not parenteral vaccines, a defect that may be amenable to intervention in part via promotion of exclusive breastfeeding. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：478 / 482

页数：5

共 22 条

[1] Chronic T cell-mediated enteropathy in rural west African children: Relationship with nutritional status and small bowel function [J].