Protective effects of plicatin B on micronucleus induction in cultured human lymphocytes by different mutagens

被引：6

作者：

Eventi, Annalisa ^{[1
]}

Lubrano, Valter ^{[2
]}

Scarpato, Roberto ^{[3
]}

Turchi, Gino ^{[1
]}

机构：

[1] IBF CNR, Biochem & Mutagenesis Somat Cells Unit, I-56124 Pisa, Italy

[2] CNR, Inst Clin Physiol, I-56100 Pisa, Italy

[3] Univ Pisa, Dept Biol, Pisa, Italy

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2009年 / 47卷 / 01期

关键词：

Chalcone plicatin B; cytotoxicity; Micronucleus; ANTIOXIDANT ACTIVITY; IN-VITRO; ANTIMUTAGENIC ACTIVITY; BIOLOGICAL EVALUATION; DNA-DAMAGE; CHALCONES; BLEOMYCIN; MECHANISMS; FLAVONOIDS; CELLS;

D O I：

10.1016/j.fct.2008.10.017

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Among flavonoids, chalcones have been identified as interesting compounds having antioxidant, antimutagenic and antitumour properties. In this study we have evaluated the clastogenicity of plicatin B on human lymphocytes (whole blood and isolated lymphocytes) and its anticlastogenic activity, in the same cellular systems, using mitomycin C (MMC), radio-mimetic bleomycin (BL) and hydrogen peroxide (H2O2) as reference clastogens. Plicatin B per se resulted cytotoxic at high dose but non-clastogenic. The clastogenic effects induced by MMC and BL were significantly reduced (-33%) whereas with H2O2 the protective effect of plicatin B was observed (-62%) only at the greater H2O2 dose. The anticlastogen effects of plicatin B were effective when the chalcone was introduced in the culture, 1 h before the reference clastogens. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：124 / 128

页数：5

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