Enzyme- and Ruthenium-Catalyzed Dynamic Kinetic Asymmetric Transformation of 1,5-Diols. Application to the Synthesis of (+)-Solenopsin A

被引：31

作者：

Leijondahl, Karin ^{[1
]}

Boren, Linnea ^{[1
]}

Braun, Roland ^{[1
]}

Backvall, Jan-E ^{[1
]}

机构：

[1] Stockholm Univ, Dept Organ Chem, Arrhenius Lab, SE-10691 Stockholm, Sweden

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 05期

基金：

瑞典研究理事会;

关键词：

SECONDARY ALCOHOLS; RESOLUTION; RACEMIZATION; LIPASE; ROUTE; COMPLEXES; PYRROLIDINE; PIPERIDINE; ALKALOIDS; ACID;

D O I：

10.1021/jo8025109

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dynamic kinetic asymmetric transformation (DYKAT) of 1,5-diols via combined lipase and ruthenium catalysis provides enantiomerically pure diacetates in high diastereoselectivity, which can serve as intermediates in natural product synthesis. This is demonstrated by the synthesis of (+)-Solenopsin A.

引用

页码：1988 / 1993

页数：6

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