Indole Synthesis via Rhodium Catalyzed Oxidative Coupling of Acetanilides and Internal Alkynes

被引：659

作者：

Stuart, David R. ^{[1
]}

Bertrand-Laperle, Megan ^{[1
]}

Burgess, Kevin M. N. ^{[1
]}

Fagnou, Keith ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 49期

关键词：

D O I：

10.1021/ja806955s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The oxidative synthesis of highly functionalized indoles from simple anilines and internal alkynes mediated by a rhodium(III) catalyst is described. Good yields are obtained for a variety of aniline substrates, and good regioselectivity is obtained for the more sterically accessible position when meta-substituted anilines are used. Symmetrical and unsymmetrical. alkynes react efficiently with high (> 40:1) C2/C3 regioselectivity when aryl/atkyl substituted alkynes are used.

引用

页码：16474 / +

页数：3

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