METTL7B promotes migration and invasion in thyroid cancer through epithelial-mesenchymal transition

被引：37

作者：

Ye, Danrong ^{[1
]}

Jiang, Yang ^{[1
]}

Sun, Yihan ^{[1
]}

Li, Yuefeng ^{[1
]}

Cai, Yefeng ^{[1
]}

Wang, Qingxuan ^{[1
]}

Wang, Ouchen ^{[1
]}

Chen, Endong ^{[1
]}

Zhang, Xiaohua ^{[1
]}

机构：

[1] Wenzhou Med Univ, Affiliated Hosp 1, Dept Thyroid & Breast Surg, Wenzhou, Zhejiang, Peoples R China

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2019年 / 63卷 / 01期

关键词：

METTL7B; thyroid cancer; epithelial-mesenchymal transition; metastasis; GENE-EXPRESSION; BRAF MUTATION; UP-REGULATION; TUMOR; TRANSFORMATION; STATISTICS; CARCINOMAS; MECHANISMS; PATHWAY; COMPLEX;

D O I：

10.1530/JME-18-0261

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thyroid cancer is associated with one of the most malignant endocrine tumors. However, molecular mechanisms underlying thyroid tumorigenesis and progression remain unclear. In order to investigate these mechanisms, we performed whole-transcriptome sequencing, which indicated that a differentially expressed gene, METTL7B, was highly expressed in thyroid cancers. We analyzed METTL7B expression using TCGA and performed qRT-PCR on tissue samples. Moreover, an analysis of clinicopathological characteristics revealed a positive correlation between METTL7B and lymph node metastasis. A series of in vitro experiments indicated that METTL7B enhanced migration and invasion of thyroid carcinoma cells. Further studies revealed that METTL7B may enhance TGF-beta 1-induced epithelial-mesenchymal transition (EMT). Our results indicate that METTL7B may promote metastasis of thyroid cancer through EMT and may therefore be considered as a potential biomarker for the diagnosis and prognosis of thyroid carcinoma.

引用

页码：51 / 61

页数：11

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