Region-specific expression of circular RNAs in the mouse brain

被引：12

作者：

Chen, Bei Jun ^{[1
]}

Yang, Belinda ^{[1
]}

Janitz, Michael ^{[1
,2
]}

机构：

[1] Univ New South Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia

[2] Univ Leipzig, Paul Flechsig Inst Brain Res, Leipzig, Germany

来源：

NEUROSCIENCE LETTERS | 2018年 / 666卷

关键词：

Circular RNAs; Transcriptome; RNA-seq; Hippocampus; Prefrontal cortex; PREFRONTAL CORTEX; HIPPOCAMPUS; INHIBITORS; TOPHAT; GENE;

D O I：

10.1016/j.neulet.2017.12.022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Circular RNAs (circRNAs) are abundant in mammalian brain and their expression is regulated in a tissue- and developmental stage-specific manner. Mammalian brain is the most transcriptionally complex organ. While many studies have extensively studied linear transcriptome and its biological functions in the brain, the circular transcriptome remains largely unexplored. This study focused on investigation of circRNA expression patterns in the mammalian brain regions critical for cognitive and memory functions and performed comparative analysis with the linear transcriptome. Altogether our study showed that circular and linear RNAs have independent expression patterns despite being derived from the same genomic locus, and that circular transcriptomes from different brain region have distinct characteristics in terms of transcript abundance and composition.

引用

页码：44 / 47

页数：4

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