Effect of combination therapy with ciprofloxacin and clarithromycin on theophylline pharmacokinetics in healthy volunteers

被引：14

作者：

Gillum, JG

Israel, DS

Scott, RB

Climo, MW

Polk, RE

机构：

[1] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,SCH PHARM,RICHMOND,VA 23298

[2] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,SCH MED,RICHMOND,VA 23298

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 07期

关键词：

D O I：

10.1128/AAC.40.7.1715

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Five adults completed this four-way randomized crossover study to compare the effects of oral treatment with ciprofloxacin, clarithromycin, and a combination of the two drugs on theophylline pharmacokinetics. The area under the concentration-time curve for theophylline during combination therapy was not different from that for ciprofloxacin alone. Beta error may explain this finding, but any real effect from combination treatment appears to be clinically unimportant.

引用

页码：1715 / 1716

页数：2

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