The role of ATP-sensitive potassium channels in cellular function and protection in the cardiovascular system

被引：109

作者：

Tinker, Andrew ^{[1
]}

Aziz, Qadeer ^{[1
]}

Thomas, Alison ^{[1
]}

机构：

[1] Barts & London Queen Marys Sch Med & Dent, William Harvey Heart Ctr, London EC1M 6BQ, England

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2014年 / 171卷 / 01期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

ATP-sensitive potassium channel; cardiac myocyte; smooth muscle; physiology; pathophysiology; PROTEIN-KINASE-C; SMOOTH-MUSCLE-CELLS; K+ CHANNELS; SULFONYLUREA RECEPTOR; EARLY REPOLARIZATION; SKELETAL-MUSCLE; CHROMOSOMAL LOCALIZATION; MYOCARDIAL-ISCHEMIA; PRESSURE-OVERLOAD; ABC TRANSPORTERS;

D O I：

10.1111/bph.12407

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

ATP-sensitive potassium channels (K-ATP) are widely distributed and present in a number of tissues including muscle, pancreatic beta cells and the brain. Their activity is regulated by adenine nucleotides, characteristically being activated by falling ATP and rising ADP levels. Thus, they link cellular metabolism with membrane excitability. Recent studies using genetically modified mice and genomic studies in patients have implicated K-ATP channels in a number of physiological and pathological processes. In this review, we focus on their role in cellular function and protection particularly in the cardiovascular system.

引用

页码：12 / 23

页数：12

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