The role of BAT in cardiometabolic disorders and aging

被引：15
作者：
Blondin, Denis P. [1 ]
Carpentier, Andre C. [1 ]
机构：
[1] Univ Sherbrooke, Dept Med, CHU Sherbrooke, Ctr Rech, Sherbrooke, PQ, Canada
来源：
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2016年 / 30卷 / 04期
基金：
加拿大健康研究院;
关键词：
energy metabolism; brown adipose tissue; aging; cardiometabolic disorders; obesity; diabetes; BROWN-ADIPOSE-TISSUE; FATTY-ACID; METABOLIC-RESPONSES; NONSHIVERING THERMOGENESIS; INSULIN SENSITIVITY; COLD-EXPOSURE; BLOOD-FLOW; OXIDATIVE-METABOLISM; OUTDOOR TEMPERATURE; LIPOPROTEIN-LIPASE;
D O I：
10.1016/j.beem.2016.09.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The demonstration of the presence of metabolically active brown adipose tissue (BAT) in adult humans using positron emission tomography (PET) over the past decade has lead to the rapid development of our knowledge regarding the role of BAT in energy metabolism in animal models and in humans. Although animal models continue to provide highly valuable information regarding the mechanisms regulating BAT development, mass and metabolic functions, these studies led to many assumptions that have been at best only partially verified in humans so far. Combined to some limitations of the current investigation approaches used in humans, this has lead to speculation on the potential role of BAT dysfunction in the development of cardiometabolic disorders and on the potential of BAT metabolic activation to treat these conditions. Here we propose a critical review of the evidence for the implication of BAT in cardiometabolic health. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：497 / 513
页数：17
相关论文
共 144 条
  • [1] Abouzied MM, 2005, J NUCL MED TECHNOL, V33, P145
  • [2] Adrenergically stimulated blood flow in brown adipose tissue is not dependent on thermogenesis
    Abreu-Vieira, Gustavo
    Hagberg, Carolina E.
    Spalding, Kirsty L.
    Cannon, Barbara
    Nedergaard, Jan
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2015, 308 (09): : E822 - E829
  • [3] Cold-induced activity of brown adipose tissue in young lean men of South-Asian and European origin
    Admiraal, W. M.
    Verberne, H. J.
    Karamat, F. A.
    Soeters, M. R.
    Hoekstra, J. B. L.
    Holleman, F.
    [J]. DIABETOLOGIA, 2013, 56 (10) : 2231 - 2237
  • [4] Brown Adipose Tissue and Seasonal Variation in Humans
    Au-Yong, Iain T. H.
    Thorn, Natasha
    Ganatra, Rakesh
    Perkins, Alan C.
    Symonds, Michael E.
    [J]. DIABETES, 2009, 58 (11) : 2583 - 2587
  • [5] Comparison of uptake of multiple clinical radiotracers into brown adipose tissue under cold-stimulated and nonstimulated conditions
    Baba, Shingo
    Engles, James M.
    Huso, David L.
    Ishimori, Takayoshi
    Wahl, Richard L.
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2007, 48 (10) : 1715 - 1723
  • [6] CNS origins of the sympathetic nervous system outflow to brown adipose tissue
    Bamshad, M
    Song, CK
    Bartness, TJ
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1999, 276 (06) : R1569 - R1578
  • [7] White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways
    Barquissau, V.
    Beuzelin, D.
    Pisani, D. F.
    Beranger, G. E.
    Mairal, A.
    Montagner, A.
    Roussel, B.
    Tavernier, G.
    Marques, M. -A.
    Moro, C.
    Guillou, H.
    Amri, E. -Z.
    Langin, D.
    [J]. MOLECULAR METABOLISM, 2016, 5 (05): : 352 - 365
  • [8] Brown adipose tissue activity controls triglyceride clearance
    Bartelt, Alexander
    Bruns, Oliver T.
    Reimer, Rudolph
    Hohenberg, Heinz
    Ittrich, Harald
    Peldschus, Kersten
    Kaul, Michael G.
    Tromsdorf, Ulrich I.
    Weller, Horst
    Waurisch, Christian
    Eychmueller, Alexander
    Gordts, Philip L. S. M.
    Rinninger, Franz
    Bruegelmann, Karoline
    Freund, Barbara
    Nielsen, Peter
    Merkel, Martin
    Heeren, Joerg
    [J]. NATURE MEDICINE, 2011, 17 (02) : 200 - U93
  • [9] Neural innervation of white adipose tissue and the control of lipolysis
    Bartness, Timothy J.
    Liu, Yang
    Shrestha, Yogendra B.
    Ryu, Vitaly
    [J]. FRONTIERS IN NEUROENDOCRINOLOGY, 2014, 35 (04) : 473 - 493
  • [10] Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
    Berbee, Jimmy F. P.
    Boon, Mariette R.
    Khedoe, P. Padmini S. J.
    Bartelt, Alexander
    Schlein, Christian
    Worthmann, Anna
    Kooijman, Sander
    Hoeke, Geerte
    Mol, Isabel M.
    John, Clara
    Jung, Caroline
    Vazirpanah, Nadia
    Brouwers, Linda P. J.
    Gordts, Philip L. S. M.
    Esko, Jeffrey D.
    Hiemstra, Pieter S.
    Havekes, Louis M.
    Scheja, Ludger
    Heeren, Joerg
    Rensen, Patrick C. N.
    [J]. NATURE COMMUNICATIONS, 2015, 6
12345678910