Neurogenesis in Neurodegenerative Diseases: Role of MFG-E8

被引：59
作者：
Cheyuo, Cletus [1 ]
Aziz, Monowar [2 ]
Wang, Ping [2 ,3 ]
机构：
[1] West Virginia Univ, Dept Neurosurg, Morgantown, WV 26506 USA
[2] Feinstein Inst Med Res, Ctr Immunol & Inflammat, Manhasset, NY 11030 USA
[3] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Surg & Mol Med, Manhasset, NY 11030 USA
来源：
FRONTIERS IN NEUROSCIENCE | 2019年 / 13卷
基金：
美国国家卫生研究院;
关键词：
neurogenesis; neurodegenerative diseases; MFG-E8; Alzheimer's disease; Parkinson's disease; stem cells; integrin; apoptosis; NEURAL STEM/PROGENITOR CELLS; CYCLIN D2; ADULT NEUROGENESIS; VASCULAR NICHE; HIPPOCAMPAL NEUROGENESIS; ASYMMETRIC INHERITANCE; SUBVENTRICULAR ZONE; CEREBRAL-HEMORRHAGE; HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASE;
D O I：
10.3389/fnins.2019.00569
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neurodegenerative diseases are devastating medical conditions with no effective treatments. Restoration of impaired neurogenesis represents a promising therapeutic strategy for neurodegenerative diseases. Milk fat globule-epidermal growth factor-factor VIII (MFG-E8) is a secretory glycoprotein that plays a wide range of cellular functions including phagocytosis of apoptotic cells, anti-inflammation, tissue regeneration, and homeostasis. The beneficial role of MFG-E8 has been shown in cerebral ischemia (stroke), neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, and traumatic brain injury. In stroke, MFG-E8 promotes neural stem cell proliferation and their migration toward the ischemic brain tissues. These novel functions of MFG-E8 are primarily mediated through its receptor alpha(v)beta(3)-integrin. Here, we focus on the pivotal role of MFG-E8 in protecting against neuronal diseases by promoting neurogenesis. We also discuss the mechanisms of MFG-E8-mediated neural stem/progenitor cell (NSPC) proliferation and migration, and the potential of MFG-E8 for neural stem cell niche maintenance via angiogenesis. We propose further investigation of the molecular pathways for MFG-E8 signaling in NSPC and effective strategies for MFG-E8 delivery across the blood-brain barrier, which will help develop MFG-E8 as a future drug candidate for the bedside management of neurodegenerative diseases.
引用
收藏
页数：9
相关论文
共 85 条
[11]   Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium [J].
Bu, Heng-Fu ;
Zuo, Xiu-Li ;
Wang, Xiao ;
Ensslin, Michael A. ;
Koti, Vjola ;
Hsueh, Wei ;
Raymond, Adam S. ;
Shur, Barry D. ;
Tan, Xiao-Di .
JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (12) :3673-3683
[12]   Absence of Preference for Social Novelty and Increased Grooming in Integrin β3 Knockout Mice: Initial Studies and Future Directions [J].
Carter, Michelle D. ;
Shah, Charisma R. ;
Muller, Christopher L. ;
Crawley, Jacqueline N. ;
Carneiro, Ana M. D. ;
Veenstra-VanderWeele, Jeremy .
AUTISM RESEARCH, 2011, 4 (01) :57-67
[13]   Milk Fat Globule-EGF Factor VIII Attenuates CNS Injury by Promoting Neural Stem Cell Proliferation and Migration after Cerebral Ischemia [J].
Cheyuo, Cletus ;
Aziz, Monowar ;
Yang, Weng-Lang ;
Jacob, Asha ;
Zhou, Mian ;
Wang, Ping .
PLOS ONE, 2015, 10 (04)
[14]   Recombinant human MFG-E8 attenuates cerebral ischemic injury: Its role in anti-inflammation and anti-apoptosis [J].
Cheyuo, Cletus ;
Jacob, Asha ;
Wu, Rongqian ;
Zhou, Mian ;
Qi, Lei ;
Dong, Weifeng ;
Ji, Youxin ;
Chaung, Wayne W. ;
Wang, Haichao ;
Nicastro, Jeffrey ;
Coppa, Gene F. ;
Wang, Ping .
NEUROPHARMACOLOGY, 2012, 62 (02) :890-900
[15]   Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles [J].
Colombo, Marina ;
Raposo, Graca ;
Thery, Clotilde .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30, 2014, 30 :255-289
[16]   Characterization and Comprehensive Proteome Profiling of Exosomes Secreted by Hepatocytes [J].
Conde-Vancells, Javier ;
Rodriguez-Suarez, Eva ;
Embade, Nieves ;
Gil, David ;
Matthiesen, Rune ;
Valle, Mikel ;
Elortza, Felix ;
Lu, Shelly C. ;
Mato, Jose M. ;
Falcon-Perez, Juan M. .
JOURNAL OF PROTEOME RESEARCH, 2008, 7 (12) :5157-5166
[17]   Quiescent neural stem cells exit dormancy upon alteration of GABAAR signaling following radiation damage [J].
Daynac, Mathieu ;
Chicheportiche, Alexandra ;
Pineda, Jose R. ;
Gauthier, Laurent R. ;
Boussin, Francois D. ;
Mouthon, Marc-Andre .
STEM CELL RESEARCH, 2013, 11 (01) :516-528
[18]   Prognosis and Neuropathologic Correlation of Clinical Subtypes of Parkinson Disease [J].
De Pablo-Fernandez, Eduardo ;
Lees, Andrew J. ;
Holton, Janice L. ;
Warner, Thomas T. .
JAMA NEUROLOGY, 2019, 76 (04) :470-479
[19]   MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury [J].
Deroide, Nicolas ;
Li, Xuan ;
Lerouet, Dominique ;
Van Vre, Emily ;
Baker, Lauren ;
Harrison, James ;
Poittevin, Marine ;
Masters, Leanne ;
Nih, Lina ;
Margail, Isabelle ;
Iwakura, Yoichiro ;
Ryffel, Bernhard ;
Pocard, Marc ;
Tedgui, Alain ;
Kubis, Nathalie ;
Mallat, Ziad .
JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (03) :1176-1181
[20]   An integrin αvβ3-c-Src oncogenic unit promotes anchorage-independence and tumor progression [J].
Desgrosellier, Jay S. ;
Barnes, Leo A. ;
Shields, David J. ;
Huang, Miller ;
Lau, Steven K. ;
Prevost, Nicolas ;
Tarin, David ;
Shattil, Sanford J. ;
Cheresh, David A. .
NATURE MEDICINE, 2009, 15 (10) :1163-U89
123456789