Clinical and Translational Research Challenges in Biliary Tract Cancers

被引:23
作者
Lamarca, Angela [1 ]
Frizziero, Melissa [1 ]
McNamara, Mairead G. [1 ,2 ]
Valle, Juan W. [1 ,2 ]
机构
[1] Christie NHS Fdn Trust, Dept Med Oncol, Wilmslow Rd, Manchester M20 4BX, Lancs, England
[2] Univ Manchester, Fac Biol Med & Hlth, Sch Med Sci, Div Mol & Clin Canc Sci, Wilmslow Rd, Manchester M20 4BX, Lancs, England
关键词
Biliary tract cancer; Cholangiocarcinoma; Gallbladder; Ampulla; Research; Challenges; Clinical; Translational; QUALITY-OF-LIFE; POSITRON-EMISSION-TOMOGRAPHY; FINE-NEEDLE-ASPIRATION; INTRAHEPATIC CHOLANGIOCARCINOMA; PHASE-II; GALLBLADDER CARCINOMA; RISK-FACTORS; LONG-TERM; PERIAMPULLARY ADENOCARCINOMA; ADJUVANT CHEMOTHERAPY;
D O I
10.2174/0929867327666200123090153
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Background: Biliary Tract Cancers (BTC) are rare malignancies with a poor prognosis. There are many challenges encountered in treating these patients in daily practice as well as in clinical, translational and basic research. Objective: This review summarises the most relevant challenges in clinical and translational research in BTCs and suggests potential solutions towards an improvement in quality of life and outcomes of patients diagnosed with such malignancies. Findings: The main challenge is the low number of patients with BTCs, complicated by the aggressive natural behaviour of cancer and the lack of funding sources for research. In addition, the clinical characteristics of these patients and the specific cancer-related complications challenge clinical research and clinical trial recruitment. It is worth highlighting that BTCs are a group of different malignancies (cholangiocarcinoma, gallbladder cancer and ampullary cancer) rather than a unique homogeneous disease. These subgroups differ not only in molecular aspects, but also in clinical and demographic characteristics. In addition, tailored imaging and quality of life assessment are required to tackle some of the issues specific to BTCs. Finally, difficulties in tissue acquisition both in terms of biopsy size and inclusion of sufficient tumour within the samples, may adversely impact translational and basic research. Conclusion: Increasing awareness among patients and clinicians regarding BTC and the need for further research and treatment development may address some of the main challenges in BTC research. International collaboration is mandatory to progress the field.
引用
收藏
页码:4756 / 4777
页数:22
相关论文
共 170 条
[1]   THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER QLQ-C30 - A QUALITY-OF-LIFE INSTRUMENT FOR USE IN INTERNATIONAL CLINICAL-TRIALS IN ONCOLOGY [J].
AARONSON, NK ;
AHMEDZAI, S ;
BERGMAN, B ;
BULLINGER, M ;
CULL, A ;
DUEZ, NJ ;
FILIBERTI, A ;
FLECHTNER, H ;
FLEISHMAN, SB ;
DEHAES, JCJM ;
KAASA, S ;
KLEE, M ;
OSOBA, D ;
RAZAVI, D ;
ROFE, PB ;
SCHRAUB, S ;
SNEEUW, K ;
SULLIVAN, M ;
TAKEDA, F .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (05) :365-376
[2]  
AbouAlfa G.K., 2019, ANN ONCOL, V30, pv851, DOI [10.1093/annonc/mdz394.., DOI 10.1016/S1470-2045(20)30157-1]
[3]   Advanced biliary tract cancer: clinical outcomes with ABC-02 regimen and analysis of prognostic factors in a tertiary care center in the United States [J].
Agarwal, Rishi ;
Sendilnathan, Arun ;
Siddiqi, Nabeela Iffat ;
Gulati, Shuchi ;
Ghose, Abhimanyu ;
Xie, Changchun ;
Olowokure, Olugbenga Olanrele .
JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2016, 7 (06) :996-1003
[4]   Treatment of unresectable intrahepatic cholangiocarcinoma with yttrium-90 radioembolization: A systematic review and pooled analysis [J].
Al-Adra, D. P. ;
Gill, R. S. ;
Axford, S. J. ;
Shi, X. ;
Kneteman, N. ;
Liau, S. -S. .
EJSO, 2015, 41 (01) :120-127
[5]   Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer [J].
Amado, Rafael G. ;
Wolf, Michael ;
Peeters, Marc ;
Van Cutsem, Eric ;
Siena, Salvatore ;
Freeman, Daniel J. ;
Juan, Todd ;
Sikorski, Robert ;
Suggs, Sid ;
Radinsky, Robert ;
Patterson, Scott D. ;
Chang, David D. .
JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (10) :1626-1634
[6]  
Amin MB., 2010, AJCC cancer staging manual, V7
[7]   Fluorodeoxyglucose PET imaging in the evaluation of gallbladder carcinoma and cholangiocarcinoma [J].
Anderson, CD ;
Rice, MH ;
Pinson, W ;
Chapman, WC ;
Chari, RS ;
Delbeke, D .
JOURNAL OF GASTROINTESTINAL SURGERY, 2004, 8 (01) :90-97
[8]  
Angela Lamarca DPHSWPRYTMAAea, 2019, J CLIN ONCOL S, V37
[9]  
[Anonymous], HEPATOLOGY
[10]  
[Anonymous], 1997, J NATL CANCER I