Programmed cell death in invertebrates

被引：94
作者：
Hengartner, MO
机构：
[1] Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, Bungtown Road
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 1996年 / 6卷 / 01期
关键词：
D O I：
10.1016/S0959-437X(96)90007-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Genetic studies of programmed cell death in Caenorhabditis elegans and Drosophila melanogaster have led to the identification of several invertebrate cell death genes. In C. elegans, ced-3 and ced-4 function to kill cells, whereas ced-9 protects cells from death. In Drosophila, the genes reaper and hid act in parallel to promote cell death. Characterization of these genes has revealed that the process of programmed cell death is evolutionarily conserved and has shed light on the molecular nature of the apoptotic machinery.
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页码：34 / 38
页数：5
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