Synthesis of Isomeric 6-Trifluoromethyl-3-azabicyclo[3.1.0]hexanes: Conformationally Restricted Analogues of 4-Trifluoromethylpiperidine

被引：39

作者：

Artamonov, Olexiy S. ^{[1
]}

Slobodyanyuk, Evgeniy Y. ^{[2
,3
,4
]}

Shishkin, Oleg V. ^{[5
]}

Komarov, Igor V. ^{[2
,3
,4
]}

Mykhailiuk, Pavel K. ^{[2
,3
,4
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02660 Kiev 94, Ukraine

[2] Enamine Ltd, UA-01103 Kiev, Ukraine

[3] Dept Chem, UA-01033 Kiev, Ukraine

[4] Kyiv Natl Taras Shevchenko Univ, UA-01033 Kiev, Ukraine

[5] Natl Acad Sci, Inst Single Crystals, STC, UA-61001 Kharkov, Ukraine

来源：

SYNTHESIS-STUTTGART | 2013年 / 45卷 / 02期

关键词：

amines; trifluoromethyl group; cyclopropane; 4-trifluoromethylpiperidine; drug design; ESTROGEN-RECEPTOR LIGANDS; MULTIGRAM SYNTHESIS; DIHYDROBENZOXATHIIN SERAMS; TRIFLUOROMETHYL GROUP; MEDICINAL CHEMISTRY; FLUORINE; CYCLOPROPANES; DERIVATIVES; DESIGN; ROUTE;

D O I：

10.1055/s-0032-1316831

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two isomeric conformationally restricted analogues of 4-trifluoromethylpiperidine were designed. The synthesis was performed in four steps from commercially available N-benzylmaleimide. The key reaction was the [3+2] cycloaddition between trifluoromethyldiazomethane and N-benzylmaleimide.

引用

页码：225 / 230

页数：6

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