Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells

被引：380

作者：

Roediger, Ben ^{[1
]}

Kyle, Ryan ^{[2
]}

Yip, Kwok Ho ^{[3
]}

Sumaria, Nital ^{[1
]}

Guy, Thomas V. ^{[1
]}

Kim, Brian S. ^{[4
,5
,6
]}

Mitchell, Andrew J. ^{[1
]}

Tay, Szun S. ^{[1
]}

Jain, Rohit ^{[1
]}

Forbes-Blom, Elizabeth ^{[2
]}

Chen, Xi ^{[7
]}

Tong, Philip L. ^{[1
,8
,9
]}

Bolton, Holly A. ^{[1
]}

Artis, David ^{[4
,5
,10
]}

Paul, William E. ^{[7
]}

Fazekas de St Groth, Barbara ^{[1
,8
]}

Grimbaldeston, Michele A. ^{[3
]}

Le Gros, Graham ^{[2
]}

Weninger, Wolfgang ^{[1
,8
,9
]}

机构：

[1] Centenary Inst, Newtown, Tas, Australia

[2] Malaghan Inst Med Res, Wellington, New Zealand

[3] SA Pathol, Ctr Canc Biol, Adelaide, SA, Australia

[4] Perelman Sch Med Philadelphia, Dept Microbiol, Philadelphia, PA USA

[5] Perelman Sch Med Philadelphia, Inst Immunol, Philadelphia, PA USA

[6] Perelman Sch Med Philadelphia, Dept Dermatol, Philadelphia, PA USA

[7] Natl Inst Allerg Dis, NIH, Bethesda, MD USA

[8] Univ Sydney, Discipline Dermatol, Camperdown, NSW, Australia

[9] Royal Prince Alfred Hosp, Dept Dermatol, Camperdown, NSW 2050, Australia

[10] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 06期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

THYMIC STROMAL LYMPHOPOIETIN; TRANSCRIPTION FACTOR GATA3; EXPRESSION; LUNG; RECEPTOR; IL-13; MICE; GENE; INTERLEUKIN-13; KERATINOCYTES;

D O I：

10.1038/ni.2584

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type 2 immunity is critical for defense against cutaneous infections but also underlies the development of allergic skin diseases. We report the identification in normal mouse dermis of an abundant, phenotypically unique group 2 innate lymphoid cell (ILC2) subset that depended on interleukin 7 (IL-7) and constitutively produced IL-13. Intravital multiphoton microscopy showed that dermal ILC2 cells specifically interacted with mast cells, whose function was suppressed by IL-13. Treatment of mice deficient in recombination-activating gene 1 (Rag1(-/-)) with IL-2 resulted in the population expansion of activated, IL-5-producing dermal ILC2 cells, which led to spontaneous dermatitis characterized by eosinophil infiltrates and activated mast cells. Our data show that ILC2 cells have both pro-and anti-inflammatory properties and identify a previously unknown interactive pathway between two innate populations of cells of the immune system linked to type 2 immunity and allergic diseases.

引用

页码：564 / +

页数：13

共 51 条

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