B-cell tolerance checkpoints in healthy humans and patients with systemic lupus erythematosus

被引：32
作者：
Yurasov, S
Hammersen, J
Tiller, T
Tsuiji, M
Wardemann, H
机构：
[1] Rockefeller Univ, Mol Immunol Lab, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Dept Pediat, New York, NY 10021 USA
[3] Univ Erlangen Nurnberg, Fac Med, Program Mol Med, D-8520 Erlangen, Germany
来源：
HUMAN IMMUNOLOGY: PATIENT-BASED RESEARCH | 2005年 / 1062卷
关键词：
B cell; tolerance; autoantibody; autoimmunity; SLE; LIGHT-CHAIN GENE; VARIABLE-REGION; AUTOANTIBODY PRODUCTION; AUTOIMMUNE-DISEASES; ESCAPE TOLERANCE; TRANSGENIC MICE; REARRANGEMENTS; ANTIBODIES; RECEPTORS; LAMBDA;
D O I：
10.1196/annals.1358.019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antibodies are protective effector molecules in the body's immune defense against pathogens. However, if directed against the body's own tissues or organs, antibodies can also play a role in the pathogenesis of autoimmune disease. Here, we discuss our data on how autoreactive antibodies are regulated in healthy humans and how a failure to establish self-tolerance during early B-cell development in patients with systemic lupus erythematosus may predispose to the development of this autoimmune disease.
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收藏
页码：165 / 174
页数：10
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