Hereditary Spherocytosis Presenting as Diffuse Bone Marrow Activation and Splenomegaly on PSMA-Targeted 18F-DCFPyL PET/CT

被引：4

作者：

Gomez, Erin ^{[1
]}

Tran, Phuoc T. ^{[2
]}

Pienta, Kenneth J. ^{[3
,4
]}

Pomper, Martin G. ^{[1
,3
,4
]}

Gorin, Michael A. ^{[1
,3
,4
]}

Rowe, Steven P. ^{[1
,3
,4
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, 600 N Wolfe St,Cent Radiol,Rm 118, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol & Mol Radiat Sci, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, James Buchanan Brady Urol Inst, Baltimore, MD USA

[4] Johns Hopkins Univ, Sch Med, Dept Urol, Baltimore, MD 21205 USA

来源：

CLINICAL NUCLEAR MEDICINE | 2019年 / 44卷 / 04期

基金：

美国国家卫生研究院;

关键词：

prostate cancer; PSMA-targeted PET; hereditary spherocytosis; PSMA-RADS; F-18-DCFPyL;

D O I：

10.1097/RLU.0000000000002489

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We present the case of a 71-year-old man with Gleason 3 + 3 = 6 pT2N0MxR0 adenocarcinoma of the prostate who presented with rising PSA level 16 years after radical prostatectomy. PSMA-targeted F-18-DCFPyL PET/CT was performed, which demonstrated recurrent disease in the prostatectomy bed as well as splenomegaly and mild-diffuse bone marrow activation, consistent with the patient's history of hereditary spherocytosis. We briefly review the clinical characteristics of hereditary spherocytosis, its appearance on molecular imaging studies, the normal biodistribution of F-18-DCFPyL, and the PSMA-RADS scoring system for characterizing findings on PSMA-targeted PET imaging.

引用

收藏

页码：E313 / E314

页数：2

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