Reduced risk of breast cancer associated with recreational physical activity varies by HER2 status

被引：13

作者：

Ma, Huiyan ^{[1
]}

Xu, Xinxin ^{[1
]}

Ursin, Giske ^{[2
,3
,9
]}

Simon, Michael S. ^{[4
]}

Marchbanks, Polly A. ^{[5
]}

Malone, Kathleen E. ^{[6
]}

Lu, Yani ^{[1
]}

McDonald, Jill A. ^{[7
]}

Folger, Suzanne G. ^{[5
]}

Weiss, Linda K. ^{[8
]}

Sullivan-Halley, Jane ^{[1
]}

Deapen, Dennis M. ^{[9
]}

Press, Michael F. ^{[10
]}

Bernstein, Leslie ^{[1
]}

机构：

[1] City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Div Canc Etiol, Duarte, CA 91010 USA

[2] Canc Registry Norway, N-0304 Oslo, Norway

[3] Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway

[4] Wayne State Univ, Karmanos Canc Inst, Dept Oncol, Detroit, MI 48201 USA

[5] Ctr Dis Control & Prevent, Div Reprod Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA 30333 USA

[6] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA

[7] New Mexico State Univ, Coll Hlth & Social Serv, Las Cruces, NM 88003 USA

[8] NCI, Canc Ctr Branch, Bethesda, MD 20850 USA

[9] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90033 USA

[10] Univ So Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90033 USA

来源：

CANCER MEDICINE | 2015年 / 4卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Breast cancer; ER; HER2; luminal A breast cancer; p53; physical activity; PR; Triple-negative breast cancer; HORMONE-RECEPTOR STATUS; ESTROGEN-RECEPTOR; REPRODUCTIVE EXPERIENCES; PROGESTERONE-RECEPTOR; P53; MUTATIONS; UNITED-STATES; WHITE WOMEN; BODY-SIZE; GENE; EXPRESSION;

D O I：

10.1002/cam4.465

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Convincing epidemiologic evidence indicates that physical activity is inversely associated with breast cancer risk. Whether this association varies by the tumor protein expression status of the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), or p53 is unclear. We evaluated the effects of recreational physical activity on risk of invasive breast cancer classified by the four biomarkers, fitting multivariable unconditional logistic regression models to data from 1195 case and 2012 control participants in the population-based Women's Contraceptive and Reproductive Experiences Study. Self-reported recreational physical activity at different life periods was measured as average annual metabolic equivalents of energy expenditure [MET]-hours per week. Our biomarker-specific analyses showed that lifetime recreational physical activity was negatively associated with the risks of ER-positive (ER+) and of HER2-negative (HER2-) subtypes (both P(trend)0.04), but not with other subtypes (all P-trend>0.10). Analyses using combinations of biomarkers indicated that risk of invasive breast cancer varied only by HER2 status. Risk of HER2-breast cancer decreased with increasing number of MET-hours of recreational physical activity in each specific life period examined, although some trend tests were only marginally statistically significant (all P(trend)0.06). The test for homogeneity of trends (HER2- vs. HER2+) reached statistical significance only when evaluating physical activity during the first 10years after menarche (P-homogeneity=0.03). Our data suggest that physical activity reduces risk of invasive breast cancers that lack HER2 overexpression, increasing our understanding of the biological mechanisms by which physical activity acts.

引用

页码：1122 / 1135

页数：14

共 60 条

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