Human immunodeficiency virus load in breast milk, mastitis, and mother-to-child transmission of human immunodeficiency virus type 1

被引：290

作者：

Semba, RD

Kumwenda, N

Hoover, DR

Taha, TE

Quinn, TC

Mtimavalye, L

Biggar, RJ

Broadhead, R

Miotti, PG

Sokoll, LJ

van der Hoeven, L

Chiphangwi, JD

机构：

[1] Johns Hopkins Univ, Dept Ophthalmol, Sch Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Dept Epidemiol, Sch Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Dept Pathol, Sch Med, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Hyg & Publ Hlth, Baltimore, MD 21205 USA

[6] NCI, Viral Epidemiol Branch, Bethesda, MD 20892 USA

[7] NIAID, NIH, Bethesda, MD 20892 USA

[8] Univ Malawi, Coll Med, Dept Obstet & Gynaecol, Blantyre, Malawi

[9] Univ Malawi, Coll Med, Dept Paediat & Child Hlth, Blantyre, Malawi

来源：

JOURNAL OF INFECTIOUS DISEASES | 1999年 / 180卷 / 01期

关键词：

D O I：

10.1086/314854

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human immunodeficiency virus (HIV) type 1 load in breast milk and mastitis were examined as risk factors for vertical transmission of HIV-1, Six weeks after delivery, HIV-1 load and sodium (an indicator of mastitis) were measured in breast milk from 334 HIV-l-infected women in Malawi, Median breast milk HIV-1 load was 700 copies/mL among women with HIV-1-infected infants versus undetectable (<200 copies/mL) among those with uninfected infants, respectively (P<.0001). Elevated breast milk sodium levels consistent with mastitis occurred in 16.4% of HIV-1-infected women and were associated with increased vertical transmission of HIV-1 (P<.0001), Median breast milk HIV-1 load was 920 copies/mL among women with versus undetectable among those without elevated breast milk sodium levels, respectively (P<.0001), Mastitis and breast milk HIV-1 load may increase the risk of vertical transmission of HIV-1 through breast-feeding.

引用

页码：93 / 98

页数：6

共 31 条

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