Quantitative magnetization transfer MRI of desmoplasia in pancreatic ductal adenocarcinoma xenografts

被引:13
作者
Li, Weiguo [1 ]
Zhang, Zhuoli [1 ,2 ]
Nicolai, Jodi [1 ]
Yang, Guang-Yu [2 ,3 ]
Omary, Reed A. [1 ,2 ,4 ]
Larson, Andrew C. [1 ,2 ,4 ]
机构
[1] Northwestern Univ, Feinberg Sch Med, Dept Radiol, Chicago, IL 60611 USA
[2] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA
[3] Northwestern Univ, Dept Pathol, Chicago, IL 60611 USA
[4] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA
基金
美国国家卫生研究院;
关键词
quantitative magnetization transfer; bound proton fraction; desmoplasia; pancreatic cancer; xenograft; IN-VIVO MT; HUMAN BRAIN; RELAXATION; CANCER; TISSUE; TUMORS; MODEL; PARAMETERS; WATER;
D O I
10.1002/nbm.3004
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Quantitative assessment of desmoplasia in pancreatic ductal adenocarcinoma (PDAC) may be critical for staging or prediction of response to therapy. We performed quantitative magnetization transfer (qMT) MRI measurements in 18 mouse xenograft tumors generated from three PDAC cell lines. The qMT parameter bound proton fraction (BPF) was found to be significantly higher in tumors grown using the BxPC-3 cell line (5.31 +/- 0.87, mean +/- standard deviation) compared with the BPF measured for tumors grown from Panc-1 (3.65 +/- 0.60) and Capan-1 (1.50 +/- 0.58) cell lines (P<0.05 for each comparison). Histologic measurements demonstrated a similar trend; BxPC-3 tumors had significantly higher fibrosis levels (percentage of fibrotic tissue area, 6.21 +/- 2.10) compared with Panc-1 (2.88 +/- 1.13) and Capan-1 (1.69 +/- 1.01) tumors. BPF was well correlated with quantitative fibrosis levels (r=0.77, P<0.01). Our results indicate that qMT measurements offer the potential to noninvasively quantify fibrosis levels in PDAC mouse xenograft models and thus serve as a valuable in vivo biomarker of desmoplasia in PDAC. Copyright (c) 2013 John Wiley & Sons, Ltd.
引用
收藏
页码:1688 / 1695
页数:8
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