Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation

被引：80
作者：
Candow, Darren G. [1 ]
Forbes, Scott C. [2 ]
Chilibeck, Philip D. [3 ]
Cornish, Stephen M. [4 ]
Antonio, Jose [5 ]
Kreider, Richard B. [6 ]
机构：
[1] Univ Regina, Fac Kinesiol & Hlth Studies, Regina, SK S4S 0A2, Canada
[2] Brandon Univ, Dept Phys Educ, Brandon, MB R7A 6A9, Canada
[3] Univ Saskatchewan, Coll Kinesiol, Saskatoon, SK S7N 5B2, Canada
[4] Univ Manitoba, Fac Kinesiol & Recreat Management, Winnipeg, MB R3T 2N2, Canada
[5] Nova Southeastern Univ, Dept Hlth & Human Performance, Davie, FL 33314 USA
[6] Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX 77843 USA
来源：
JOURNAL OF CLINICAL MEDICINE | 2019年 / 8卷 / 04期
关键词：
sarcopenia; dynapenia; mechanisms; exercise; functionality; safety; IMPROVES MUSCULAR PERFORMANCE; MONOHYDRATE SUPPLEMENTATION; OXIDATIVE STRESS; SKELETAL-MUSCLE; NUTRITIONAL INTERVENTIONS; BODY-COMPOSITION; MINERAL DENSITY; KINASE ACTIVITY; OLDER-ADULTS; STRENGTH;
D O I：
10.3390/jcm8040488
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Sarcopenia, defined as the age-related decrease in muscle mass, strength and physical performance, is associated with reduced bone mass and elevated low-grade inflammation. From a healthy aging perspective, interventions which overcome sarcopenia are clinically relevant. Accumulating evidence suggests that exogenous creatine supplementation has the potential to increase aging muscle mass, muscle performance, and decrease the risk of falls and possibly attenuate inflammation and loss of bone mineral. Therefore, the purpose of this review is to: (1) summarize the effects of creatine supplementation, with and without resistance training, in aging adults and discuss possible mechanisms of action, (2) examine the effects of creatine on bone biology and risk of falls, (3) evaluate the potential anti-inflammatory effects of creatine and (4) determine the safety of creatine supplementation in aging adults.
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页数：15
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