Synthesis and In Vitro Anticancer Activity of Novel 1,3,4-Oxadiazole-Linked 1,2,3-Triazole/Isoxazole Hybrids

被引：18

作者：

Madhavilatha, B. ^{[1
]}

Bhattacharjee, Debanjan ^{[2
]}

Sabitha, Gowravaram ^{[1
,3
]}

Reddy, B. V. Subba ^{[3
,4
]}

Yadav, J. S. ^{[3
,4
]}

Jain, Nishant ^{[2
]}

Reddy, B. Jagan Mohan ^{[5
]}

机构：

[1] CSIR Indian Inst Chem Technol, Nat Prod Chem Div, Hyderabad 500007, Andhra Pradesh, India

[2] CSIR Indian Inst Chem Technol, Ctr Chem Biol, Hyderabad 500007, Andhra Pradesh, India

[3] Acad Sci & Innovat Res AcSIR, 2 Rafi Marg, New Delhi 110001, India

[4] CSIR Indian Inst Chem Technol, Ctr Semiochem, Hyderabad 500007, Andhra Pradesh, India

[5] Adikavi Nannaya Univ, Dept Chem, Rajahmundry 533296, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 04期

关键词：

BIOLOGICAL EVALUATION; ANTIINFLAMMATORY ACTIVITY; SULFONE DERIVATIVES; BEARING OXADIAZOLE; CELL-LINES; MOIETY; AGENTS; INHIBITORS; DESIGN; ANALOGS;

D O I：

10.1002/jhet.3110

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new 1,3,4-oxadiazole-linked 1,2,3-triazole/isoxazole derivatives were designed and synthesized. All the synthesized compounds were screened for in vitro anticancer activity against four human cancer cells: HeLa (cervical), MDA-MB-231 (breast), DU-145 (prostate), and HEPG2 (liver). Among 17 compounds tested, 7a, 7c, and 7d showed potent activity toward four cell lines.

引用

页码：863 / 870

页数：8

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