Transformation of 3-(3-arylalkylcarbamoyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-1-yl)propanenitriles into amides and acids

被引：4

作者：

Ukrainets, I. V. ^{[1
]}

Gorokhova, O. V. ^{[1
]}

Andreeva, K. V. ^{[1
]}

机构：

[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 49卷 / 06期

关键词：

EFFICIENT CONVERSION; HYDROGEN-PEROXIDE; NITRILES;

D O I：

10.1134/S1070428013060122

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mixture of hydrochloric and acetic acids depleted in water was proposed to effect stepwise transformation of 3-(3-arylalkylcarbamoyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-1-yl)propanenitriles into the corresponding amides and then into the acids. The procedure turned out to be efficient with 3-[(2-phenylethyl)-carbamoyl] derivatives, whereas the reactions with benzylcarbamoyl analogs were accompanied by partial or complete debenzylation.

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收藏

页码：867 / 871

页数：5

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