New-generation therapy for ANCA-associated vasculitis

被引：4

作者：

Jayne, David ^{[1
]}

机构：

[1] Univ Cambridge, Dept Med, Cambridge CB2 2QQ, England

来源：

CLINICAL AND EXPERIMENTAL NEPHROLOGY | 2013年 / 17卷 / 05期

关键词：

Vasculitis; ANCA; Therapy; Clinical trial; Rituximab; RITUXIMAB; CYCLOPHOSPHAMIDE; MAINTENANCE; TRIAL;

D O I：

10.1007/s10157-013-0855-z

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Newer therapies for systemic vasculitis are required to improve the efficacy and reduce the toxicity associated with current agents. Our understanding of its pathogenesis is increasing with the availability of targeted therapies. B-cell depletion with rituximab is now a licensed therapy for ANCA vasculitis. Targets for therapy currently in development in ANCA associated vasculitis include blockade of complement and pro-inflammatory cytokines, and inhibition of T cell co-stimulation.

引用

页码：694 / 696

页数：3

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