Antifungal and antibacterial naphthoquinones from Newbouldia laevis roots

被引：128

作者：

Gafner, S

Wolfender, JL

Nianga, M

StoeckliEvans, H

Hostettmann, K

机构：

[1] UNIV LAUSANNE, INST PHARMACOGNOSIE & PHYTOCHIM, BEP, CH-1015 LAUSANNE, SWITZERLAND

[2] LACONA, CONAKRY, GUINEA

[3] UNIV NEUCHATEL, INST CHIM, CH-2000 NEUCHATEL, SWITZERLAND

来源：

PHYTOCHEMISTRY | 1996年 / 42卷 / 05期

关键词：

Newbouldia laevis; Bignoniaceae; roots; naphthoquinones; antifungal activity; antibacterial activity;

D O I：

10.1016/0031-9422(96)00135-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

From a dichloromethane extract of Newbouldia laevis roots, four new (6-hydroxydehydroiso-alpha-lapachone, 7-hydroxydehydroiso-alpha-lapachone, 5,7-dihydroxydehydroiso-alpha-lapachone and 3-hydroxy-5-methoxydehydroiso-alpha-lapachone) and six known naphthoquinones have been isolated. Their structures were established by spectroscopic methods (UV, EI mass spectrometry, H-1 and C-13 NMR) and that of 7-hydroxydehydroiso-alpha-lapachone was confirmed by X-ray crystallography. All naphthoquinones showed antifungal activity against Cladosporium cucumerinum and Candida albicans, and activity against the bacteria Bacillus subtilis and Escherichia coli.

引用

页码：1315 / 1320

页数：6

共 25 条

[1] PYRAZOLE ALKALOIDS FROM NEWBOULDIA-LAEVIS [J].