Antifungal and antibacterial naphthoquinones from Newbouldia laevis roots

被引：128
作者：
Gafner, S
Wolfender, JL
Nianga, M
StoeckliEvans, H
Hostettmann, K
机构：
[1] UNIV LAUSANNE, INST PHARMACOGNOSIE & PHYTOCHIM, BEP, CH-1015 LAUSANNE, SWITZERLAND
[2] LACONA, CONAKRY, GUINEA
[3] UNIV NEUCHATEL, INST CHIM, CH-2000 NEUCHATEL, SWITZERLAND
来源：
PHYTOCHEMISTRY | 1996年 / 42卷 / 05期
关键词：
Newbouldia laevis; Bignoniaceae; roots; naphthoquinones; antifungal activity; antibacterial activity;
D O I：
10.1016/0031-9422(96)00135-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
From a dichloromethane extract of Newbouldia laevis roots, four new (6-hydroxydehydroiso-alpha-lapachone, 7-hydroxydehydroiso-alpha-lapachone, 5,7-dihydroxydehydroiso-alpha-lapachone and 3-hydroxy-5-methoxydehydroiso-alpha-lapachone) and six known naphthoquinones have been isolated. Their structures were established by spectroscopic methods (UV, EI mass spectrometry, H-1 and C-13 NMR) and that of 7-hydroxydehydroiso-alpha-lapachone was confirmed by X-ray crystallography. All naphthoquinones showed antifungal activity against Cladosporium cucumerinum and Candida albicans, and activity against the bacteria Bacillus subtilis and Escherichia coli.
引用
收藏
页码：1315 / 1320
页数：6
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