Biosynthesis of an organofluorine molecule - A fluorinase enzyme has been discovered that catalyses carbon-fluorine bond formation.

被引:325
作者
O'Hagan, D
Schaffrath, C
Cobb, SL
Hamilton, JTG
Murphy, CD
机构
[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland
[2] Univ St Andrews, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland
[3] Queens Univ Belfast, Dept Food Sci, Microbial Biochem Sect, Belfast BT9 SPX, Antrim, North Ireland
关键词
D O I
10.1038/416279a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A fluorinase enzyme has been discovered that catalyses carbon-fluorine bond formation.
引用
收藏
页码:279 / 279
页数:1
相关论文
共 9 条
[1]   THE BASE-SUGAR CONFORMATION OF CERTAIN DERIVATIVES OF ADENOSINE [J].
GANI, D ;
JOHNSON, AW .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1982, (05) :1197-1204
[2]   The diversity of naturally occurring organobromine compounds [J].
Gribble, GW .
CHEMICAL SOCIETY REVIEWS, 1999, 28 (05) :335-346
[3]   DISTRIBUTION OF ORGANIC FLUORINE IN SOME TOXIC TROPICAL PLANTS [J].
HALL, RJ .
NEW PHYTOLOGIST, 1972, 71 (05) :855-+
[4]   THE FLUORINATED NATURAL-PRODUCTS [J].
HARPER, DB ;
OHAGAN, D .
NATURAL PRODUCT REPORTS, 1994, 11 (02) :123-133
[5]   Fluoroacetaldehyde:: a precursor of both fluoroacetate and 4-fluorothreonine in Streptomyces cattleya [J].
Moss, SJ ;
Murphy, CD ;
Hamilton, JTG ;
McRoberts, WC ;
O'Hagan, D ;
Schaffrath, C ;
Harper, DB .
CHEMICAL COMMUNICATIONS, 2000, (22) :2281-2282
[6]   Isolation of an aldehyde dehydrogenase involved in the oxidation of fluoroacetaldehyde to fluoroacetate in Streptomyces cattleya [J].
Murphy, CD ;
Moss, SJ ;
O'Hagan, D .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2001, 67 (10) :4919-4921
[7]  
O'Hagan D, 2000, ACS SYM SER, V746, P210
[8]   OBSERVATIONS ON METABOLISM OF FLUORIDE IN ACACIA GEORGINAE AND SOME OTHER PLANTS [J].
PETERS, RA ;
SHORTHOU.M .
NATURE, 1967, 216 (5110) :80-&
[9]   BIOSYNTHESIS OF FLUOROTHREONINE AND FLUOROACETIC ACID BY THE THIENAMYCIN PRODUCER, STREPTOMYCES-CATTLEYA [J].
SANADA, M ;
MIYANO, T ;
IWADARE, S ;
WILLIAMSON, JM ;
ARISON, BH ;
SMITH, JL ;
DOUGLAS, AW ;
LIESCH, JM ;
INAMINE, E .
JOURNAL OF ANTIBIOTICS, 1986, 39 (02) :259-265