Small RNAs derived from the 5 end of tRNA can inhibit protein translation in human cells

被引：280

作者：

Sobala, Andrew ^{[1
]}

Hutvagner, Gyorgy ^{[1
,2
]}

机构：

[1] Univ Dundee, Wellcome Trust Ctr Gene Regulat & Express, Dundee, Scotland

[2] Univ Technol Sydney, Ctr Hlth Technol, Fac Engn & Informat Technol, Sydney, NSW 2007, Australia

来源：

RNA BIOLOGY | 2013年 / 10卷 / 04期

基金：

英国惠康基金;

关键词：

tRNA; short tRNA fragment; tRF; translation repression; small RNA; MESSENGER-RNA; OXIDATIVE STRESS; REPRESSION; INITIATION; CLEAVAGE; SIRNAS; INTERFERENCE; ARGONAUTE2; PREDICTION; DICER;

D O I：

10.4161/rna.24285

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, it has been shown that tRNA molecules can be processed into small RNAs that are derived from both the 5 and 3 termini. To date, the function of these tRNA fragments (tRFs) derived from the 5 end of tRNA has not been investigated in depth. We present evidence that conserved residues in tRNA, present in all 5 tRFs, can inhibit the process of protein translation without the need for complementary target sites in the mRNA. These results implicate 5 tRFs in a new mechanism of gene regulation by small RNAs in human cells.

引用

页码：553 / 563

页数：11

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