MicroRNAs in hematological malignancies

被引：60

作者：

Lawrie, Charles H. ^{[1
,2
,3
]}

机构：

[1] Biodonostia Res Inst, San Sebastian 20014, Spain

[2] Basque Fdn Sci, IKERBASQUE, Bilbao, Spain

[3] Univ Oxford, Nuffield Dept Clin Lab Sci, Oxford, England

来源：

BLOOD REVIEWS | 2013年 / 27卷 / 03期

关键词：

miRNA; microRNA; Lymphoma; Leukemia; Myeloma; Hematological malignancy; Hematopoiesis; Biomarker; Therapy; ACUTE MYELOID-LEUKEMIA; B-CELL LYMPHOMA; CHRONIC LYMPHOCYTIC-LEUKEMIA; NF-KAPPA-B; ACUTE LYMPHOBLASTIC-LEUKEMIA; INDUCED CYTIDINE DEAMINASE; RNA-BINDING PROTEIN; TUMOR-SUPPRESSOR; MIRNA EXPRESSION; DOWN-REGULATION;

D O I：

10.1016/j.blre.2013.04.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MicroRNAs (miRNAs) have become one of the hottest topics in biology over recent years, but remarkably have only been formally recognized for just over 10 years. These endogenously produced short (19-24 nt) non-coding RNAs have introduced an entirely new paradigm in our understanding of gene control and it is now evident that miRNAs play a crucial regulatory role in many, if not all, physiological and pathological processes. In this review we provide an overview of the role and potential clinical utility for miRNAs in hematological malignancies and their function in normal hematopoiesis. Although still in its infancy, the miRNA field has already added much to our understanding of hematological processes, and provides us with novel tools as both biomarkers and therapeutic agents for hematological malignancies. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：143 / 154

页数：12

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