Synthesis and Characterization of Novel Unsymmetrical and Symmetrical 3-Halo- or 3-Methoxy-substituted 2-Dibenzoylamino-1,4-naphthoquinone Derivatives

被引：13

作者：

Brandy, Yakini ^{[1
]}

Brandy, Nailah ^{[1
]}

Akinboye, Emmanuel ^{[1
]}

Lewis, Malik ^{[1
]}

Mouamba, Claudia ^{[1
]}

Mack, Seshat ^{[1
]}

Butcher, Ray J. ^{[1
]}

Anderson, Alan J. ^{[2
]}

Bakare, Oladapo ^{[1
]}

机构：

[1] Howard Univ, Dept Chem, Washington, DC 20059 USA

[2] Bowie State Univ, Dept Nat Sci, Bowie, MD 20715 USA

来源：

MOLECULES | 2013年 / 18卷 / 02期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

1,4-naphthoquinone; imide synthesis; sodium hydride-promoted bis-acylation; unsymmetrical imide; BIOLOGICAL EVALUATION; NAPHTHOQUINONE DERIVATIVES; HETEROCYCLIC QUINONES; CYTOTOXICITY; 2,3-DICHLORO-5,8-DIMETHOXY-1,4-NAPHTHOQUINONE; INHIBITORS; DISRUPTS; TUBULIN; DESIGN;

D O I：

10.3390/molecules18021973

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Symmetrical and unsymmetrical 3-halo- or 3-methoxy- substituted 2-dibenzoylamino-1,4-naphthoquinone analogs were synthesized with an average yield of 45% via sodium hydride promoted bis-acylation of 2-amino-3-chloro-1,4-naphthoquinone, 2-amino-3-bromo-1,4-naphthoquinone and 2-amino-3-methoxy-1,4-naphthoquinone.

引用

收藏

页码：1973 / 1984

页数：12

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