Synthesis and antimicrobial activity of 5-(1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazole derivatives

被引：6

作者：

Krolenko, Konstantin Yu. ^{[1
]}

Vlasov, Sergiy V. ^{[1
]}

Zhuravel, Irina A. ^{[1
]}

机构：

[1] Natl Univ Pharm, 53 Pushkinska St, UA-61002 Kharkov, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2016年 / 52卷 / 10期

关键词：

1,2,3-triazole; piperidine ring; pyrrolidine ring; acylation; antimicrobial activity; ANTIFUNGAL AGENTS; COMPLEXES; 1,2,3-TRIAZOLES; PALLADIUM; SAR;

D O I：

10.1007/s10593-016-1972-x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New 5-(1H-1,2,3-triazol-4-yl)-1,2,4-oxadiazole derivatives containing piperidine or pyrrolidine ring were synthesized and found to exhibit strong antimicrobial activity. A structure-activity study of the antimicrobial effect was performed for these compounds.

引用

页码：823 / 830

页数：8

共 21 条

[1]

[Anonymous], 2012, M100S22 CLSI, V32, P169

[2]

Bartolozzi A., WO Patent, Patent No. 2012040139

[3]

Bumagin N., 2016, IZV AKAD NAUK K, P321

[4] Functionally substituted isoxazoles and isothiazoles: Synthesis, palladium(II) complexes and their catalytic activity [J].

Bumagin, N. A. ;

Zelenkovskii, V. M. ;

Kletskov, A. V. ;

Petkevich, S. K. ;

Dikusar, E. A. ;

Potkin, V. I. .

RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2016, 86 (01) :68-81

[5] Isoxazol-3-yl(Isothiazol-3-yl)-1,2,4-Triazoles, -Tetrazoles, and-1,3,4-Oxadiazoles: Synthesis, Palladium Complexes, and Catalytic Applications [J].

Bumagin, N. A. ;

Petkevich, S. K. ;

Kletskov, A. V. ;

Livantsov, M. V. ;

Golantsov, N. E. ;

Potkin, V. I. .

CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2014, 49 (10) :1515-1529

[6]

Coyle M. B., 2005, MANUAL ANTIMICROBIAL, p[29, 39]

[7] A novel amalgamation of 1,2,3-triazoles, piperidines and thieno pyridine rings and evaluation of their antifungal activity [J].

Darandale, Sunil N. ;

Mulla, Nayeem A. ;

Pansare, Dattatraya N. ;

Sangshetti, Jaiprakash N. ;

Shinde, Devanand B. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 65 :527-532

[8] Parallel synthesis of 1,2,4-oxadiazoles using CDI activation [J].

Deegan, TL ;

Nitz, TJ ;

Cebzanov, D ;

Pufko, DE ;

Porco, JA .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (02) :209-212

[9] Reactions of β-Azolylenamines with Sulfonyl Azides as an Approach to N-Unsubstituted 1,2,3-Triazoles and Ethene-1,2-diamines [J].

Efimov, Ilya ;

Bakulev, Vasiliy ;

Beliaev, Nikolai ;

Beryozkina, Tetyana ;

Knippschild, Uwe ;

Leban, Johann ;

Zhi-Jin, Fan ;

Eltsov, Oleg ;

Slepukhin, Pavel ;

Ezhikova, Marina ;

Dehaen, Wim .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2014, 2014 (17) :3684-3689

[10]

Hatley R. J. D., WO Patent, Patent No. 2007017262

← 1 2 3 →