Dean flow assisted cell ordering system for lipid profiling in single-cells using mass spectrometry

被引：67
作者：
Huang, Qiushi [1 ]
Mao, Sifeng [1 ]
Khan, Mashooq [1 ]
Zhou, Lin [1 ]
Lin, Jin-Ming [1 ]
机构：
[1] Tsinghua Univ, Beijing Key Lab Micronalyt Methods & Instrumentat, Dept Chem, MOE Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 21期
基金：
国家重点研发计划; 中国博士后科学基金; 中国国家自然科学基金;
关键词：
LABEL-FREE; SEPARATION; PROBE; DIFFERENTIATION; METABOLISM; EXPRESSION;
D O I：
10.1039/c7cc09608a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This study describes a novel Dean flow assisted cell ordering system which is connected to an electrospray ionization-mass spectrometer for the detection of lipids in a single-cell. This platform provides a facile method for direct analysis of label-free lipids in single-cells and significantly improves the efficiency of single-cellmass spectrometry.
引用
收藏
页码：2595 / 2598
页数：4
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