A self-assembled cyclodextrin nanocarrier for photoreactive squaraine

被引：9

作者：

Kauscher, Ulrike

Ravoo, Bart Jan ^{[1
]}

机构：

[1] Westfal Wilhelms Univ Munster, Inst Organ Chem, Corrensstr 40, D-48149 Munster, Germany

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 12卷

关键词：

cyclodextrin; host-guest chemistry; photodynamic therapy; self-assembly; squaraine; SINGLET OXYGEN GENERATION; PHOTODYNAMIC THERAPY; PHTHALOCYANINE; VESICLES; PHOTOSENSITIZERS; PORPHYRIN; CHEMISTRY; CARRIER; SURFACE; DYES;

D O I：

10.3762/bjoc.12.248

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Photoreactive squaraines produce cytotoxic oxygen species under irradiation and have significant potential for photodynamic therapy. Herein we report that squaraines can be immobilized on a self-assembled nanocarrier composed of amphiphilic cyclodextrins to enhance their photochemical activity. To this end, a squaraine was equipped with two adamantane moieties that act as anchors for the cyclodextrin vesicle surface. The supramolecular immobilization was monitored by using fluorescence spectroscopy and microscopy and the photochemistry of the squaraine was investigated by using absorption spectroscopy.

引用

页码：2535 / 2542

页数：8

共 40 条

[1] Singlet Oxygen Generation by Novel NIR BODIPY Dyes [J].