Reduced information transmission in the internal segment of the globus pallidus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced rhesus monkey models of Parkinson's disease

被引：0

作者：

He, Yan ^{[1
,2
]}

Wang, Jue ^{[1
,2
]}

Gao, Guodong ^{[3
]}

Zhang, Guangjun ^{[1
,2
]}

机构：

[1] Xi An Jiao Tong Univ, Natl Engn Res Ctr Hlth Care & Med Devices, Key Lab Biomed Informat Engn, Xian Jiaotong Univ Branch,Minist Educ, Xian 710049, Shaanxi Provinc, Peoples R China

[2] Xi An Jiao Tong Univ, Natl Engn Res Ctr Hlth Care & Med Devices, Inst Biomed Engn, Xian Jiaotong Univ Branch,Sch Life Sci & Technol, Xian 710049, Shaanxi Provinc, Peoples R China

[3] Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian 710038, Shaanxi Provinc, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 26期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

neuronal oscillation; microelectrode; Parkinson's disease; wavelet packet decomposition; singular value; neural regeneration; BASAL GANGLIA; FEATURE-EXTRACTION; DYNAMICS; OSCILLATIONS; NUCLEUS; CORTEX;

D O I：

10.3969/j.issn.1673-5374.2012.26.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rhesus monkey models of Parkinson's disease were induced by injection of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neural firings were recorded using microelectrodes placed in the internal segment of the globus pallidus. The wavelets and power spectra show gradual power reduction during the disease process along with increased firing rates in the Parkinson's disease state. Singular values of coefficients decreased considerably during tremor-related activity as well as in the Parkinson's disease state compared with normal signals, revealing that higher-frequency components weaken when Parkinson's disease occurs. We speculate that the death of neurons could be reflected by irregular frequency spike trains, and that wavelet packet decomposition can effectively detect the degradation of neurons and the loss of information transmission in the neural circuitry.

引用

页码：2028 / 2035

页数：8

共 41 条

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