Synthesis and antimicrobial screening of 4-thiazolidinone and 2-azetidinone derivatives of piperazine

被引：14

作者：

Shingade, Sunil G. ^{[1
]}

Bari, Sanjaykumar B. ^{[1
]}

机构：

[1] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Dhule 425405, Maharashtra, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2013年 / 22卷 / 02期

关键词：

Piperazine; Schiff bases; 4-Thiazolidinone; 2-Azetidinone; Antimicrobial activity; ANTIBACTERIAL ACTIVITY; ANTIMALARIAL EVALUATION; N-ALKYL;

D O I：

10.1007/s00044-012-0063-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The Schiff's bases 3a-3h were synthesized by reacting substituted/unsubstituted aromatic aldehydes 2a-2h with 1-(2-aminoethyl)-piperazine 1. A series of novel aryl-3-(2-piperazin-1-ylethyl)-1,3-thiazolidin-4-one 4a-4h and 3-chloro-1-{2-[4-(chloroacetyl)piperazin-1-yl]ethyl}-4-arylazetidin-2-one 5a-5h were synthesized from the Schiff's bases of 1-(2-aminoethyl)-piperazine 3a-3h. The structures of synthesized compounds were confirmed by analytical (C, H, and N) and spectral (FT-IR, H-1 NMR, C-13 NMR, and Mass) data. The compounds 4a-4h and 5a-5h were screened for antimicrobial activity. The compounds 4a, 4d, 4f, 4g, 5a, 5d, 5f, and 5g exhibited substantially significant antibacterial as well as antifungal activity.

引用

页码：699 / 706

页数：8

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