Combined Electrochemistry and Surface-Enhanced Infrared Absorption Spectroscopy of Gramicidin A Incorporated into Tethered Bilayer Lipid Membranes

被引：59
作者：
Kozuch, Jacek [1 ]
Steinem, Claudia [3 ]
Hildebrandt, Peter [1 ]
Millo, Diego [2 ]
机构：
[1] Tech Univ Berlin, Inst Chem, D-10623 Berlin, Germany
[2] Vrije Univ Amsterdam, Biomol Spectroscopy LaserLaB Amsterdam, NL-1081 HV Amsterdam, Netherlands
[3] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 32期
关键词：
bilayer lipid membranes; electrochemistry; gramicidin A; ion channels; SEIRA; TRANSPORT; PROTEINS; CHANNELS; HELIX;
D O I：
10.1002/anie.201203214
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Support from the support: Tethered bilayer lipid membranes containing the cation-channel-forming peptide gramicidin A were assembled on nanostructured Au films. The combination of surface-enhanced infrared absorption (SEIRA) and electrochemical impedance spectroscopy (EIS) was used for the in situ structural and functional characterization of gramicidin A in the same device. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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页码：8114 / 8117
页数：4
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