Molecular mechanism of signaling by tumor necrosis factor

被引：5

作者：

Zha, JK

Shu, HB ^{[1
]}

机构：

[1] Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China

[2] Natl Jewish & Res Ctr, Denver, CO 80206 USA

来源：

SCIENCE IN CHINA SERIES C-LIFE SCIENCES | 2002年 / 45卷 / 02期

关键词：

tumor necrosis factor; signal transduction; JNK kinase; NF-kappa B; apoptosis;

D O I：

10.1360/02yc9013

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tumor necrosis factor (TNF) is an important cytokine with multiple biological effects, including cell growth, differentiation, apoptosis, immune regulation and induction of inflammation. The effects of TNF are mediated by two receptors, TNF-R1 and TNF-R2. The major signal transduction pathways triggered by TNF include those that lead to apoptosis, activation of transcription factor NF-kappaB and protein kinase JNK This review will discuss the molecular mechanisms of these signaling pathways.

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收藏

页码：113 / 119

页数：7

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