Synthesis and hetero-Diels-Alder reactions of enantiomerically pure dihydro-1H-azepines

被引：11

作者：

Craig, Donald ^{[1
]}

Spreadbury, Samuel R. J. ^{[1
]}

White, Andrew J. P. ^{[2
]}

机构：

[1] Imperial Coll London, Dept Chem, Mol Sci Res Hub, White City Campus,Wood Lane, London W12 0BZ, England

[2] Imperial Coll London, Chem Crystallog Lab, Mol Sci Res Hub, White City Campus,Wood Lane, London W12 0BZ, England

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 68期

基金：

英国工程与自然科学研究理事会;

关键词：

GLYCOSIDASE INHIBITORS; RING-EXPANSION; 1,4-BIS(ARYLSULFONYL)-1,2,3,4-TETRAHYDROPYRIDINES; ACCESS; TRANSFORMATIONS; CYCLOADDITION; IMINOSUGARS; AZEPANES; ADDUCT;

D O I：

10.1039/d0cc04413j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Thermolysis of enantiomerically pure 3-substituted 7,7-dihalo-2-azabicyclo[4.1.0]heptanes in the presence of K(2)CO(3)gives in good yields 2-alkyl-6-halo-1-tosyl-2,3-dihydro-1H-azepines. These undergo highly stereoselective [4+2] cycloaddition reactions with heterodienophiles and arylation/alkenylation under Suzuki conditions.

引用

页码：9803 / 9806

页数：4

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