Glycosaminoglycan and versican deposits in taxane-induced sclerosis

被引：10

作者：

Okada, K. ^{[1
]}

Endo, Y. ^{[1
]}

Miyachi, Y. ^{[1
]}

Koike, Y. ^{[2
]}

Kuwatsuka, Y. ^{[2
]}

Utani, A. ^{[2
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Dermatol, Kyoto 6068507, Japan

[2] Nagasaki Univ, Grad Sch Biomed Sci, Dept Dermatol, Nagasaki 8528501, Japan

来源：

BRITISH JOURNAL OF DERMATOLOGY | 2015年 / 173卷 / 04期

关键词：

SYSTEMIC-SCLEROSIS; DOCETAXEL TAXOTERE; BREAST-CANCER; SCLERODERMA; ASSOCIATION; PACLITAXEL;

D O I：

10.1111/bjd.13899

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Docetaxel and paclitaxel are widely used in the treatment of various malignant neoplasms. Taxane-induced sclerosis is dose-dependent and usually not generalized. Little information on the pathogenesis of scleroderma is currently available. Here, we report a case of generalized scleroderma and a case of early-stage oedematous sclerosis, both of which presented with intense versican deposits after administration of taxane for angiosarcoma.

引用

页码：1054 / 1058

页数：5

共 16 条

[1] DISACCHARIDE ANALYSIS OF THE SKIN GLYCOSAMINOGLYCANS IN SYSTEMIC-SCLEROSIS [J].