Influence of growth hormone on circulating fibroblast growth factor 21 levels in humans

被引:20
|
作者
Lundberg, J. [1 ,2 ]
Hoybye, C. [3 ]
Krusenstjerna-Hafstrom, T. [4 ]
Bina, H. A. [5 ]
Kharitonenkov, A. [5 ]
Angelin, B. [1 ,2 ]
Rudling, M. [1 ,2 ]
机构
[1] Karolinska Univ, Dept Endocrinol Metab & Diabet, Karolinska Inst, Huddinge Hosp,Metab Unit,Dept Med,Ctr Biosci,NOVU, Stockholm, Sweden
[2] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Mol Nutr Unit,Ctr Biosci,NOVUM, Stockholm, Sweden
[3] Karolinska Univ, Hosp Solna, Karolinska Inst, Dept Endocrinol Metab & Diabet,Dept Mol Med & Sur, Stockholm, Sweden
[4] Aarhus Univ Hosp, Dept Internal Med & Endocrinol, DK-8000 Aarhus, Denmark
[5] Div Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN USA
基金
瑞典研究理事会;
关键词
FGF21; GH; NEFA; oral glucose test; BILE-ACID SYNTHESIS; PPAR-ALPHA; REGULATOR; FGF21;
D O I
10.1111/joim.12112
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. Findings from animal studies indicate that growth hormone (GH) may stimulate the production of the putative metabolic regulator fibroblast growth factor 21 (FGF21). We investigated whether circulating FGF21 levels are altered in patients with GH deficiency and characterized how levels of this growth factor are influenced by acute and long-term administration of GH, and the potential relationship between FGF21 and nonesterified fatty acids (NEFAs). Design and setting. GH-deficient patients (n = 9) were studied prior to and during 1 year of replacement with GH. Healthy subjects (n = 8) received an intravenous bolus of GH with or without concomitant oral glucose. Healthy subjects and patients with heterozygous familial hypercholesterolaemia (n = 23) were monitored following increasing doses of GH for 3 weeks. The main outcome measures were serum FGF21 and NEFA levels. Studies were performed at two academic centres. Results. GH-deficient patients had FGF21 levels within the normal range, and GH replacement did not influence circulating FGF21 or NEFA concentrations. Acute GH administration to healthy control subjects did not change FGF21 levels, whereas an oral glucose load increased serum FGF21 by 25% and reduced NEFA levels by 48%. Similar effects were seen on administration of glucose together with GH. However, FGF21 levels increased dose dependently up to 3.7-fold in control subjects treated with GH for 3 weeks; simultaneously NEFA levels were increased by 47%. Conclusions. GH is not critical for the maintenance of basal serum FGF21 levels in humans, but circulating FGF21 levels increase following administration of GH to healthy individuals. There is no correlation between plasma NEFA and circulating FGF21 levels.
引用
收藏
页码:227 / 232
页数:6
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