TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

被引：188

作者：

Meller, Stephan ^{[1
,2
]}

Di Domizio, Jeremy ^{[3
]}

Voo, Kui S. ^{[1
]}

Friedrich, Heike C. ^{[2
]}

Chamilos, Georgios ^{[1
,4
]}

Ganguly, Dipyaman ^{[1
]}

Conrad, Curdin ^{[3
]}

Gregorio, Josh ^{[1
]}

Le Roy, Didier ^{[5
]}

Roger, Thierry ^{[5
]}

Ladbury, John E. ^{[6
]}

Homey, Bernhard ^{[2
]}

Watowich, Stanley ^{[7
]}

Modlin, Robert L. ^{[8
]}

Kontoyiannis, Dimitrios P. ^{[4
]}

Liu, Yong-Jun ^{[9
]}

Aroldl, Stefan T. ^{[10
]}

Gilliet, Michel ^{[1
,3
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

[2] Univ Dusseldorf, Fac Med, Dept Dermatol, Dusseldorf, Germany

[3] CHU Vaudois, Univ Hosp, Dept Dermatol, CH-1011 Lausanne, Switzerland

[4] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis, Houston, TX 77030 USA

[5] CHU Vaudois, Univ Hosp, Dept Infect Dis, CH-1011 Lausanne, Switzerland

[6] Univ Leeds, Sch Mol & Cell Biol, Leeds, W Yorkshire, England

[7] Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA

[8] Univ Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Los Angeles, CA 90095 USA

[9] MedImmune, Dept Resp Inflammat & Autoimmun, Gaithersburg, MD USA

[10] King Abdullah Univ Sci & Technol, Div Biol & Environm Sci & Engn, Thuwal, Saudi Arabia

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 09期

基金：

瑞士国家科学基金会;

关键词：

PLASMACYTOID DENDRITIC CELLS; GROWTH-FACTOR-BETA; I INTERFERON; ANTIMICROBIAL PEPTIDES; CRYSTAL-STRUCTURE; INDUCTION; DIFFERENTIATION; SUSCEPTIBILITY; RECRUITMENT; DEFICIENCY;

D O I：

10.1038/ni.3211

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin 17-producing helper T cells (T(H)17 cells) have a major role in protection against infections and in mediating autoimmune diseases, yet the mechanisms involved are incompletely understood. We found that interleukin 26 (IL-26), a human T(H)17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria via membrane-pore formation. Furthermore, T(H)17 cell-derived IL-26 formed complexes with bacterial DNA and self-DNA released by dying bacteria and host cells. The resulting IL-26-DNA complexes triggered the production of type I interferon by plasmacytoid dendritic cells via activation of Toll-like receptor 9, but independently of the IL-26 receptor. These findings provide insights into the potent antimicrobial and proinflammatory function of T(H)17 cells by showing that IL-26 is a natural human antimicrobial that promotes immune sensing of bacterial and host cell death.

引用

页码：970 / 979

页数：10

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