Nickel Catalyzed Ipso-hydroxylation and Subsequent Cross Dehydrogenative Coupling of Arylboronic Acids with Tertiary Amines: A Facile Access to α-phenolated Tertiary Amines

被引：16

作者：

Kumar, Promod ^{[1
]}

Sharma, Anup Kumar ^{[1
]}

Singh, Rahul ^{[1
]}

Guntreddi, Tirumaleswararao ^{[1
]}

Singh, Krishna Nand ^{[1
]}

机构：

[1] Banaras Hindu Univ, Inst Sci, Ctr Adv Study, Dept Chem, Varanasi 221005, Uttar Pradesh, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2018年 / 360卷 / 09期

关键词：

C-H functionalization; Nickel; Phenols; Ipso-hydroxylation; Tertiary amines; BOND FORMATION SYNTHESIS; C-O; ARYLATION; CYCLIZATION; ACTIVATION; DISCOVERY; STRATEGY;

D O I：

10.1002/adsc.201701625

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A straightforward and new approach has been developed for the alpha-functionalization of tertiary amines via sequential oxidative hydoxylation and cross-dehydrogenative coupling (CDC) of arylboronic acids with tertiary amines to afford alpha-phenolated tertiary amines. The results demonstrate an easy arylation of C(sp(3))-H bond in the presence of an inexpensive and readily available nickel metal salt.

引用

页码：1786 / 1789

页数：4