Nickel Catalyzed Ipso-hydroxylation and Subsequent Cross Dehydrogenative Coupling of Arylboronic Acids with Tertiary Amines: A Facile Access to α-phenolated Tertiary Amines

被引：16
|
作者：
Kumar, Promod [1 ]
Sharma, Anup Kumar [1 ]
Singh, Rahul [1 ]
Guntreddi, Tirumaleswararao [1 ]
Singh, Krishna Nand [1 ]
机构：
[1] Banaras Hindu Univ, Inst Sci, Ctr Adv Study, Dept Chem, Varanasi 221005, Uttar Pradesh, India
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2018年 / 360卷 / 09期
关键词：
C-H functionalization; Nickel; Phenols; Ipso-hydroxylation; Tertiary amines; BOND FORMATION SYNTHESIS; C-O; ARYLATION; CYCLIZATION; ACTIVATION; DISCOVERY; STRATEGY;
D O I：
10.1002/adsc.201701625
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A straightforward and new approach has been developed for the alpha-functionalization of tertiary amines via sequential oxidative hydoxylation and cross-dehydrogenative coupling (CDC) of arylboronic acids with tertiary amines to afford alpha-phenolated tertiary amines. The results demonstrate an easy arylation of C(sp(3))-H bond in the presence of an inexpensive and readily available nickel metal salt.
引用
收藏
页码：1786 / 1789
页数：4
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