TGF-β family members and gonadal development

被引：45
作者：
Josso, N [1 ]
di Clemente, N [1 ]
机构：
[1] Ecole Normale Super, Dept Biol, INSERM, Unite Rech Endocrinol Dev, F-92120 Montrouge, France
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1999年 / 10卷 / 06期
关键词：
D O I：
10.1016/S1043-2760(99)00155-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Several members of the transforming growth factor beta (TGF-beta) family are involved in gonadal development; namely, TGF-beta itself, inhibins, activins, anti-Mullerian hormone (AMH) and GDF-9, These proteins do not affect initial gonadal organogenesis but play either a stimulatory or inhibitory role in the division and differentiation of gonadal cells and in meiotic maturation in the female. Furthermore as shown by transgenic mouse technology, both AMH and inhibin act as tumor suppressors.
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收藏
页码：216 / 222
页数：7
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