Up-regulation of cyclooxygenase-2 expression in lymphocytic thyroiditis and thyroid tumors - Significant correlation with inducible nitric oxide synthase

被引：0
作者：
Nose, F
Ichikawa, T
Fujiwara, M
Okayasu, I
机构：
[1] Kitasato Univ, Sch Med, Dept Pathol, Sagamihara, Kanagawa 2288555, Japan
[2] Japanese Red Cross Med Ctr, Dept Clin Pathol, Tokyo, Japan
来源：
AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2002年 / 117卷 / 04期
关键词：
thyroiditis; thyroid tumorigenesis; cyclooxygenase-2; inducible nitric oxide synthase; nitric oxide; apoptosis;
D O I：
暂无
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
To cast light on relations of cyclooxygenase-2 (COX-2) expression to lymphocytic thyroiditis and thyroid tumorigenesis, protein levels were immuno-histochemically assessed and compared with inducible nitric oxide synthase (iNOS) in a total of 181 cases: follicular adenoma, 23; well-differentiated papillary carcinoma, 85; poorly differentiated papillary carcinoma, 25; anaplastic carcinoma, 7; and follicular carcinoma, 41. In addition, 72 specimens of normal follicular epithelia and 36 of lymphocytic thyroiditis were used as control samples. Immunohistochemical results were confirmed in 2 cases each of normal thyroid, lymphocytic thyroiditis, and well-differentiated and poorly differentiated papillary carcinoma, by Western blotting assay. Stepwise increments in overexpression of COX-2 and iNOS were revealed in epithelial cells of lymphocytic thyroiditis, follicular adenoma, and papillary carcinoma; normal thyroid epithelium showed little expression. A significant positive correlation between the 2 enzymes was found with all cases. Enhanced expression of both COX-2 and iNOS suggests important roles in the inflammatory processes underlying lymphocytic thyroiditis and thyroid tumorigenesis.
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收藏
页码：546 / 551
页数：6
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