Airway smooth muscle in the pathophysiology and treatment of asthma

被引：127
作者：
Doeing, Diana C. [1 ]
Solway, Julian [1 ]
机构：
[1] Univ Chicago, Dept Med, Chicago, IL 60637 USA
来源：
JOURNAL OF APPLIED PHYSIOLOGY | 2013年 / 114卷 / 07期
基金：
美国国家卫生研究院;
关键词：
airflow obstruction; inflammation; airway remodeling; GROWTH-FACTOR-BETA; ADRENERGIC-RECEPTOR POLYMORPHISMS; MEDIATED CA2+ SENSITIZATION; MAST-CELL; RHO-KINASE; BRONCHIAL THERMOPLASTY; EOSINOPHILIC ASTHMA; TGF-BETA; IN-VITRO; BETA-2-ADRENERGIC RECEPTOR;
D O I：
10.1152/japplphysiol.00950.2012
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Airway smooth muscle in the pathophysiology and treatment of asthma. J Appl Physiol 114: 834-843, 2013. First published January 10, 2013; doi:10.1152/japplphysiol.00950.2012.-Airway smooth muscle (ASM) plays an integral part in the pathophysiology of asthma. It is responsible for acute bronchoconstriction, which is potentiated by constrictor hyperresponsiveness, impaired relaxation and length adaptation. ASM also contributes to airway remodeling and inflammation in asthma. In light of this, ASM is an important target in the treatment of asthma.
引用
收藏
页码：834 / 843
页数：10
相关论文
共 151 条
[71]   Polymorphisms of the ADAM33 gene are associated with accelerated lung function decline in asthma [J].
Jongepier, H ;
Boezen, HM ;
Dijkstra, A ;
Howard, TD ;
Vonk, JM ;
Koppelman, GH ;
Zheng, SL ;
Meyers, DA ;
Bleecker, ER ;
Postma, DS .
CLINICAL AND EXPERIMENTAL ALLERGY, 2004, 34 (05) :757-760
[72]   Randomised, dose-ranging, placebo-controlled study of chimeric antibody to CD4 (keliximab) in chronic severe asthma [J].
Kon, OM ;
Sihra, BS ;
Compton, CH ;
Leonard, TB ;
Kay, AB ;
Barnes, NC .
LANCET, 1998, 352 (9134) :1109-1113
[73]   The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+T-cells in asthma [J].
Kon, OM ;
Sihra, BS ;
Loh, LC ;
Barkans, J ;
Compton, CH ;
Barnes, NC ;
Larché, M ;
Kay, AB .
EUROPEAN RESPIRATORY JOURNAL, 2001, 18 (01) :45-52
[74]   Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients [J].
Labuda, Malgorzata ;
Laberge, Sophie ;
Briere, Julie ;
Berube, Denis ;
Beaulieu, Patrick ;
Pastinen, Tomi ;
Krajinovic, Maja .
MEDIATORS OF INFLAMMATION, 2011, 2011
[75]   Steroids augment relengthening of contracted airway smooth muscle: potential additional mechanism of benefit in asthma [J].
Lakser, O. J. ;
Dowell, M. L. ;
Hoyte, F. L. ;
Chen, B. ;
Lavoie, T. L. ;
Ferreira, C. ;
Pinto, L. H. ;
Dulin, N. O. ;
Kogut, P. ;
Churchill, J. ;
Mitchell, R. W. ;
Solway, J. .
EUROPEAN RESPIRATORY JOURNAL, 2008, 32 (05) :1224-1230
[76]   Inhibition of the p38 MAP kinase pathway destabilizes smooth muscle length during physiological loading [J].
Lakser, OJ ;
Lindeman, RP ;
Fredberg, JJ .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2002, 282 (05) :L1117-L1121
[77]   FUNCTIONAL-SIGNIFICANCE OF INCREASED AIRWAY SMOOTH-MUSCLE IN ASTHMA AND COPD [J].
LAMBERT, RK ;
WIGGS, BR ;
KUWANO, K ;
HOGG, JC ;
PARE, PD .
JOURNAL OF APPLIED PHYSIOLOGY, 1993, 74 (06) :2771-2781
[78]   Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells [J].
Laporte, JC ;
Moore, PE ;
Baraldo, S ;
Jouvin, MH ;
Church, TL ;
Schwartzman, IN ;
Panettieri, RA ;
Kinet, JP ;
Shore, SA .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 164 (01) :141-148
[79]   p38 MAP kinase regulates IL-1β responses in cultured airway smooth muscle cells [J].
Laporte, JD ;
Moore, PE ;
Lahiri, T ;
Schwartzman, IN ;
Panettieri, RA ;
Shore, SA .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2000, 279 (05) :L932-L941
[80]   Dilatation of the Constricted Human Airway by Tidal Expansion of Lung Parenchyma [J].
Lavoie, Tera L. ;
Krishnan, Ramaswamy ;
Siegel, Harrison R. ;
Maston, Essence D. ;
Fredberg, Jeffrey J. ;
Solway, Julian ;
Dowell, Maria L. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 186 (03) :225-232
3456789101112